Product image of Levothyroxine Sodium Aristo (Anhydrous Levothyroxine Sodium) supplied by GNH India

Levothyroxine Sodium Aristo

Active Ingredient:
Anhydrous Levothyroxine Sodium
Origin:
EU

Levothyroxine Sodium Aristo (Anhydrous Levothyroxine Sodium)

Levothyroxine sodium, the active ingredient in Levothyroxine Sodium Aristo, is a thyroid hormone replacement presented as an oral tablet for oral use. It replaces deficient thyroid hormone, treating hypothyroidism, goiter and supporting patients after thyroidectomy and helps normalize metabolic function in adults.

GNH India supplies Levothyroxine Sodium Aristo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with robust quality assurance, regulatory compliance, and reliable logistics to meet global demand, ensuring product integrity from manufacturing to delivery for patient care.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Levothyroxine sodium is used to replace deficient thyroid hormone in disorders of the hypothalamic‑pituitary‑thyroid axis.

  • Hypothyroidism: restores normal thyroid hormone levels, improving metabolic rate and symptom control.
  • Goiter: reduces thyroid‑stimulating hormone drive, helping to decrease gland enlargement.
  • Post‑thyroidectomy: provides necessary thyroid hormone replacement after surgical removal of the thyroid gland.
  • Subclinical hypothyroidism: normalizes TSH levels in patients with mild deficiency.

How It Works

  • Levothyroxine is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active triiodothyronine (T3) within peripheral tissues. The hormone binds nuclear thyroid receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth, thereby compensating for endogenous hormone deficiency.

Side Effects

Levothyroxine may cause a range of adverse reactions, most of which are dose‑related.

Common Side Effects

  • Palpitations: sensation of rapid or irregular heartbeat.
  • Tremor: fine shaking of hands or limbs.
  • Insomnia: difficulty falling or staying asleep.
  • Weight loss: unintended reduction in body weight.
  • Heat intolerance: increased sensitivity to warm environments.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythm that may require medical attention.
  • Angina: chest pain due to reduced blood flow to the heart.
  • Osteoporosis: decreased bone density with long‑term overtreatment.
  • Allergic reaction: rash, itching, swelling, or angioedema.
  • Severe hyperthyroid symptoms: anxiety, agitation, or muscle weakness.

Precautions & Warnings

Levothyroxine therapy requires careful monitoring and individualized dosing.

  • Dose adjustment: titrate based on TSH levels and clinical response.
  • Cardiovascular disease: use caution in patients with coronary artery disease.
  • Pregnancy: monitor thyroid function closely if prescribed during pregnancy.
  • Elderly: start with lower dose to avoid overtreatment.
  • Drug interactions: review concomitant medications that affect absorption.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levothyroxine absorption and activity can be altered by several concomitant drugs.

Major Interactions (Avoid)

  • Calcium or iron supplements: significantly reduce levothyroxine absorption.
  • Antacids containing aluminum or magnesium: impair absorption.
  • Warfarin: may increase anticoagulant effect, requiring INR monitoring.
  • Amiodarone: can alter thyroid hormone levels and require dose adjustment.
  • Cholestyramine: decreases bioavailability of levothyroxine.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hyperthyroidism.
  • Corticosteroids: may increase hormone requirements.

Frequently Asked Questions

Levothyroxine Sodium Aristo is prescribed to treat hypothyroidism, reduce goiter size, and provide thyroid hormone replacement after thyroidectomy. It supplies the missing thyroxine (T4) hormone, helping to normalize metabolism and support normal growth and development in patients with deficient thyroid function.

Levothyroxine sodium is a synthetic form of the natural hormone thyroxine (T4). After oral absorption, it is converted to the active triiodothyronine (T3) in peripheral tissues. The hormone binds to nuclear thyroid receptors, influencing gene expression that controls basal metabolic rate, protein synthesis, and growth, thereby compensating for low endogenous hormone levels.

The appropriate dose of Levothyroxine Sodium Aristo is individualized and set by a qualified prescriber based on factors such as the patient’s age, weight, severity of hypothyroidism, and laboratory TSH results. Dosage adjustments are made during follow‑up visits to achieve optimal thyroid hormone levels.

Levothyroxine is generally considered safe for use during pregnancy and lactation when medically indicated, as untreated hypothyroidism can harm both mother and fetus. However, thyroid function should be closely monitored, and dose adjustments may be required. Patients should discuss any concerns with their healthcare provider.

To request Levothyroxine Sodium Aristo, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levothyroxine Sodium Aristo is a generic formulation of levothyroxine, offering the same active ingredient as brand‑name products such as Synthroid or Eltroxin. Clinical efficacy and safety are comparable when taken as prescribed, while generic versions often provide cost advantages for healthcare systems and patients.

Levothyroxine Sodium Aristo should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight, and ensure the packaging remains tightly closed to maintain product stability.

Levothyroxine Sodium Aristo is taken orally, usually on an empty stomach, at least 30 minutes before breakfast or any other medication. Swallow the tablet whole with a full glass of water; do not crush or chew it, as this can affect absorption.

Serious risks include cardiac arrhythmias, angina, and severe hyperthyroid symptoms such as anxiety, tremor, or muscle weakness, especially if the dose is too high. Long‑term overtreatment can also lead to osteoporosis. Patients should report any chest pain, rapid heartbeat, or unexplained weight loss to their clinician promptly.

Levothyroxine Sodium Aristo is contraindicated in patients with known hypersensitivity to levothyroxine or any of the tablet’s excipients. Caution is advised for individuals with untreated adrenal insufficiency, recent myocardial infarction, or uncorrected thyrotoxicosis. A healthcare professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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