Product image of L-Тироксин Берлин-Хеми (Levothyroxine Sodium, Hydrate) supplied by GNH India

L-Тироксин Берлин-Хеми

Active Ingredient:
Levothyroxine Sodium, Hydrate
Origin:
EU

L-Тироксин Берлин-Хеми (Levothyroxine Sodium, Hydrate)

Levothyroxine sodium hydrate, the active ingredient in L‑Тироксин Берлин‑Хеми, is a synthetic thyroid hormone presented as an oral tablet for systemic use. It replaces or supplements endogenous thyroxine, thereby normalizing metabolic activity in patients with hypothyroidism, thyroid hormone deficiency after thyroidectomy, or goiter.

GNH India supplies L‑Тироксин Берлин‑Хеми as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under strict quality standards. The company ensures reliable logistics and regulatory compliance for each shipment, enabling consistent availability across diverse markets.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Levothyroxine sodium hydrate is used to treat conditions related to thyroid hormone deficiency.

  • Hypothyroidism: restores normal thyroid hormone levels, relieving fatigue, weight gain, and cold intolerance.
  • Post‑thyroidectomy hormone replacement: supplies needed thyroxine after surgical removal of the thyroid gland.
  • Goiter: reduces thyroid-stimulating hormone drive, helping to control gland enlargement.

How It Works

  • Levothyroxine sodium hydrate is a synthetic analogue of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active form triiodothyronine (T3) within peripheral tissues, binding to nuclear thyroid hormone receptors and modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. This restores normal metabolic function in patients lacking sufficient thyroid hormone.

Side Effects

Levothyroxine sodium hydrate may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Insomnia: difficulty falling or staying asleep.
  • Nervousness or anxiety: heightened nervous system activity.
  • Increased appetite: may lead to weight changes.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Weight loss: due to elevated metabolic rate.

Serious or Rare Side Effects

  • Cardiac arrhythmias: irregular heart rhythms, especially in patients with heart disease.
  • Chest pain: possible sign of myocardial ischemia.
  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Osteoporosis: long‑term excess may reduce bone density.
  • Hyperthyroid symptoms: tremor, heat intolerance, excessive sweating.
  • Acute thyrotoxicosis: dangerous over‑replacement of thyroid hormone.

Precautions & Warnings

Before initiating therapy, certain precautions should be observed.

  • Dose adjustment: monitor TSH and free T4 levels regularly to individualize dosing.
  • Cardiovascular disease: use caution in patients with angina, arrhythmias, or recent myocardial infarction.
  • Pregnancy: consult a healthcare professional; therapy may be required but should be carefully managed.
  • Elderly patients: start with a lower dose and titrate slowly to avoid overtreatment.
  • Drug interactions: review all concomitant medications for potential effects on levothyroxine absorption or activity.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levothyroxine sodium hydrate can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Amiodarone: may alter thyroid hormone metabolism and require dose adjustments.
  • Antacids containing aluminum or magnesium: reduce levothyroxine absorption; separate dosing by at least 4 hours.
  • Warfarin: levothyroxine can increase anticoagulant effect, necessitating closer INR monitoring.

Moderate Interactions (Monitor Closely)

  • Calcium supplements: may decrease levothyroxine absorption; advise spacing doses.
  • Estrogen therapy (including oral contraceptives): can increase levothyroxine requirement.
  • Cholesterol‑lowering agents such as cholestyramine or colestipol: may bind levothyroxine and reduce its effectiveness.

Frequently Asked Questions

L‑Тироксин Берлин‑Хеми contains levothyroxine sodium hydrate, which is prescribed to replace or supplement thyroid hormone in patients with hypothyroidism, to provide hormone replacement after thyroidectomy, and to help manage goiter by normalizing thyroid‑stimulating hormone levels.

Levothyroxine sodium hydrate is a synthetic form of thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues, binds to nuclear thyroid receptors, and regulates gene expression that controls metabolism, growth, and protein synthesis, thereby restoring normal physiological function.

The appropriate dose is individualized. A prescribing healthcare professional determines the amount based on the patient’s age, weight, severity of thyroid deficiency, and laboratory measurements such as TSH and free T4. Dosage is typically adjusted gradually to achieve target hormone levels.

Levothyroxine is generally considered safe when used under medical supervision during pregnancy and lactation because adequate thyroid hormone is essential for fetal development. However, treatment should only be continued if the prescriber judges that the benefits outweigh any potential risks, and thyroid function should be closely monitored.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

The primary alternative is liothyronine (T3) or combination therapy with desiccated thyroid extract. Levothyroxine provides a stable T4 source that the body converts to T3 as needed, offering more predictable dosing and a longer half‑life. Liothyronine acts faster but may require multiple daily doses and carries a higher risk of rapid over‑replacement.

Store the tablets at temperatures below 25 °C in their original packaging. Protect them from moisture, excessive heat, and direct sunlight. Do not store in bathrooms or near kitchen sinks. Keep out of reach of children and discard any tablets that appear discolored or damaged.

The medication is taken orally, usually once daily on an empty stomach, at least 30 minutes before breakfast, with a full glass of water. Swallow the tablet whole; do not crush or chew. Consistent timing each day helps maintain stable hormone levels.

Serious risks include signs of overtreatment such as rapid heart rate, chest pain, arrhythmias, severe anxiety, or bone loss (osteoporosis) with long‑term excess. Allergic reactions like rash, swelling, or difficulty breathing also require immediate medical attention. Regular monitoring of thyroid function tests helps prevent these complications.

Patients with untreated adrenal insufficiency, acute myocardial infarction, or uncorrected hyperthyroidism should avoid levothyroxine until those conditions are managed. Individuals with known hypersensitivity to levothyroxine or any tablet excipients should also not use this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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