Product image of Levotiroxina (Anhydrous Levothyroxine Sodium) supplied by GNH India

Levotiroxina

Active Ingredient:
Anhydrous Levothyroxine Sodium
Origin:
EU

Levotiroxina (Anhydrous Levothyroxine Sodium)

Levothyroxine, the active ingredient in Levotiroxina, is a thyroid hormone replacement presented as an oral tablet for oral use. It is used to treat hypothyroidism and related thyroid disorders by restoring deficient thyroid hormone levels in patients of all ages.

GNH India supplies Levotiroxina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets. The company adheres to stringent manufacturing standards and provides reliable logistics for timely delivery.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Levotiroxina is a synthetic thyroid hormone that acts on the endocrine system to correct deficient hormone production.

  • Hypothyroidism: restores normal thyroid hormone levels, relieving fatigue, weight gain, and cold intolerance.
  • Goiter: reduces thyroid gland enlargement by normalizing hormone feedback mechanisms.
  • Post‑thyroidectomy hormone replacement: provides the necessary thyroxine to maintain metabolic balance after surgical removal of the thyroid gland.

How It Works

  • Levothyroxine is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. T3 binds nuclear thyroid hormone receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth, thereby normalizing systemic metabolic functions.

Side Effects

Levotiroxina may cause a range of adverse reactions, most of which are dose‑related.

Common Side Effects

  • Headache: mild to moderate headache occurring after dose initiation.
  • Insomnia: difficulty falling or staying asleep, especially with higher doses.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Weight loss: unintended reduction in body weight.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythms that may require medical attention.
  • Angina or myocardial infarction: chest pain or heart attack in susceptible patients.
  • Osteoporosis: decreased bone mineral density with long‑term overtreatment.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate care.

Precautions & Warnings

When prescribing Levotiroxina, clinicians should consider several safety measures.

  • Dose adjustment: monitor thyroid function tests regularly and titrate dose accordingly.
  • Cardiovascular disease: initiate therapy at low dose and increase cautiously.
  • Elderly patients: start with reduced dose due to altered metabolism.
  • Pregnancy: use only under medical supervision after risk‑benefit assessment.
  • Drug interactions: review concomitant medications that may affect absorption or metabolism.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levotiroxina can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Amiodarone: may cause excess thyroid hormone levels.
  • Antithyroid drugs (e.g., methimazole, propylthiouracil): antagonize Levotiroxina's effect.
  • Calcium or iron supplements: significantly reduce Levotiroxina absorption.

Moderate Interactions (Monitor Closely)

  • Warfarin: Levotiroxina may alter INR, requiring closer monitoring.
  • Oral contraceptives: can increase circulating thyroid hormone levels.
  • Rifampin: may increase Levotiroxina metabolism, reducing its effectiveness.

Frequently Asked Questions

Levotiroxina is prescribed for patients with hypothyroidism, an underactive thyroid, to normalize hormone levels. It is also used to manage goiter by correcting hormonal imbalances and to provide thyroid hormone replacement after thyroidectomy, ensuring metabolic stability.

Levothyroxine is a synthetic form of the natural hormone T4. After oral absorption, it is converted to the active hormone T3, which binds to nuclear receptors and regulates gene expression, thereby increasing basal metabolic rate and restoring normal physiological functions.

The appropriate dose of Levotiroxina is individualized. A qualified prescriber determines the starting dose based on the patient’s age, weight, cardiac status, and thyroid function test results, then adjusts it to achieve target hormone levels.

Levotiroxina may be used during pregnancy and lactation when clearly needed, as untreated hypothyroidism can harm both mother and fetus. Treatment should be guided by a healthcare professional who will monitor thyroid function closely.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levotiroxina is the standard synthetic T4 replacement and is generally preferred for its predictable pharmacokinetics. Alternatives such as liothyronine (T3) or combination T4/T3 therapy may be used in specific cases, but Levotiroxina remains the first‑line option for most patients.

Levotiroxina should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, light, and excessive heat to maintain potency throughout its shelf life.

Levotiroxina is taken orally, usually once daily on an empty stomach, preferably 30‑60 minutes before breakfast. The tablet should be swallowed whole with a glass of water and not crushed or chewed.

Serious risks include cardiac arrhythmias, angina, myocardial infarction, and severe bone loss (osteoporosis) when overtreatment leads to excessive thyroid hormone levels. Patients should be monitored regularly for symptoms and laboratory values.

Levotiroxina is contraindicated in patients with untreated adrenal insufficiency, acute myocardial infarction, or known hypersensitivity to levothyroxine or any excipients. Caution is also advised for individuals with uncorrected cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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