Product image of Levotiroxina Sanofi (Levothyroxine Sodium) supplied by GNH India

Levotiroxina Sanofi

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

Levotiroxina Sanofi (Levothyroxine Sodium)

Levothyroxine sodium, the active ingredient in Levotiroxina Sanofi, is a thyroid hormone presented as an intravenous solution for intravenous use. It is employed to treat hypothyroidism, myxedema coma, and to provide thyroid hormone replacement after thyroidectomy or to suppress goiter growth.

GNH India supplies Levotiroxina Sanofi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable logistics for global distribution.

Manufacturer / TM Owner

Sanofi-Aventis, S.A.

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Indications & Clinical Uses

Levotiroxina Sanofi is used in thyroid‑related disorders to restore normal hormone levels.

  • Hypothyroidism: restores normal thyroid hormone concentrations, relieving symptoms of low metabolic rate.
  • Myxedema coma: provides rapid hormone replacement to reverse life‑threatening metabolic collapse.
  • Post‑thyroidectomy replacement: supplies necessary thyroid hormone after surgical removal of the gland.
  • Goiter suppression: reduces thyroid‑stimulating hormone drive to limit goiter growth.

How It Works

  • Levothyroxine sodium is a synthetic analogue of endogenous thyroxine (T4). After intravenous administration, it enters cells and binds to nuclear thyroid hormone receptors, modulating gene transcription that increases basal metabolic rate, enhances protein synthesis, and regulates growth and development processes throughout the body.

Side Effects

Levotiroxina Sanofi may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Nausea: transient gastrointestinal upset.
  • Insomnia: difficulty falling or staying asleep.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Heat intolerance: increased sensitivity to warm environments.
  • Tremor: fine shaking of hands or limbs.

Serious or Rare Side Effects

  • Cardiac arrhythmia: potentially life‑threatening rhythm disturbances.
  • Angina or myocardial infarction: chest pain or heart attack in susceptible patients.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hyperthyroidism: excessive hormone effect causing weight loss, anxiety, and tachycardia.
  • Bone loss: accelerated osteoporosis with long‑term overtreatment.

Precautions & Warnings

Levotiroxina Sanofi requires careful clinical monitoring.

  • Dose adjustment: modify dose in elderly, renal or hepatic impairment.
  • Cardiovascular monitoring: observe patients with coronary artery disease or arrhythmias.
  • Pregnancy: use only when clearly needed, after risk‑benefit assessment.
  • Drug interactions: review concomitant medications that may alter thyroid hormone levels.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levotiroxina Sanofi can interact with several medicines.

Major Interactions (Avoid)

  • Amiodarone: may cause excess thyroid hormone activity.
  • Warfarin: levothyroxine can increase anticoagulant effect, raising bleeding risk.
  • Antacids containing aluminum or magnesium: reduce levothyroxine absorption.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of excess thyroid hormone.
  • Corticosteroids: can increase metabolism of levothyroxine.
  • Estrogen therapy: may raise thyroid‑binding globulin, altering hormone levels.

Frequently Asked Questions

Levotiroxina Sanofi is an intravenous levothyroxine formulation used to replace deficient thyroid hormone in conditions such as hypothyroidism, myxedema coma, after thyroidectomy, and to suppress goiter growth. It provides a rapid and controlled increase in circulating T4 levels, helping to normalize metabolism and related physiological functions.

Levothyroxine sodium is a synthetic form of the natural hormone thyroxine (T4). After entering the bloodstream, it binds to nuclear thyroid hormone receptors in target cells, influencing gene expression that raises basal metabolic rate, enhances protein synthesis, and regulates growth and development throughout the body.

The dose of Levotiroxina Sanofi is individualized by the prescribing clinician based on the patient’s age, weight, severity of thyroid deficiency, cardiac status, and laboratory thyroid‑stimulating hormone (TSH) levels. No fixed regimen is provided; the prescriber determines the appropriate amount and infusion rate.

Safety data for levothyroxine sodium in pregnancy and lactation are limited. It should be used only when clearly indicated, after a careful risk‑benefit assessment by the treating physician. If prescribed, close monitoring of maternal thyroid function and fetal development is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Levotiroxina Sanofi delivers levothyroxine intravenously, offering rapid hormone replacement compared with oral levothyroxine tablets, which require gastrointestinal absorption. Compared with liothyronine (T3) preparations, levothyroxine has a longer half‑life and provides a more stable, physiologic hormone profile, making it the preferred choice for most replacement therapies.

Store Levotiroxina Sanofi at ambient temperature, below 25 °C, in its original packaging. Protect the solution from direct light, moisture, and extreme temperature fluctuations. Do not freeze. Inspect the container for any signs of contamination before use.

Levotiroxina Sanofi is given as an intravenous infusion. The solution is added to a compatible IV fluid bag or syringe and administered over a period determined by the prescribing clinician, typically ranging from a few minutes to several hours, depending on the clinical situation.

The most serious risks include cardiac arrhythmias, angina or myocardial infarction in patients with underlying heart disease, severe allergic reactions (anaphylaxis), and overt hyperthyroidism leading to rapid weight loss, anxiety, tremor, and bone loss. Immediate medical attention is required if any of these occur.

Levotiroxina Sanofi should be avoided in patients with untreated adrenal insufficiency, uncorrected thyrotoxicosis, or known hypersensitivity to levothyroxine or any component of the formulation. Caution is also advised for individuals with recent myocardial infarction or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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