Product image of Levotuss Tosse (Levodropropizine) supplied by GNH India

Levotuss Tosse

Active Ingredient:
Levodropropizine
Origin:
EU

Levotuss Tosse (Levodropropizine)

Levodropropizine, the active ingredient in Levotuss Tosse, is a peripheral antitussive presented as an oral formulation for systemic use. It is used to suppress cough reflexes in patients with acute or chronic cough, particularly when the cough is non‑productive and causes discomfort. Levotuss Tosse is marketed in the European Union and is supplied without a specified strength or dosage form.

GNH India supplies Levotuss Tosse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dompé Farmaceutici S.P.A.

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Indications & Clinical Uses

Levodropropizine acts on the peripheral cough pathway to alleviate coughing associated with respiratory irritation.

  • Acute cough: reduces the frequency and intensity of coughing episodes during short‑term respiratory infections.
  • Chronic cough: helps control persistent cough when underlying causes have been evaluated.
  • Non‑productive cough: eases irritation‑driven cough without sputum production, improving patient comfort.

How It Works

  • Levodropropizine exerts its antitussive effect by acting peripherally on sensory C‑fibers located in the respiratory mucosa. It inhibits the transmission of afferent signals from these fibers to the cough centre in the brainstem, thereby lowering the cough reflex sensitivity without central nervous system depression.

Side Effects

Levodropropizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Dry mouth: mild reduction in salivary flow.
  • Nausea: occasional feeling of stomach upset.
  • Dizziness: transient light‑headedness.
  • Headache: mild to moderate pain.
  • Gastrointestinal discomfort: mild abdominal pain or dyspepsia.

Serious or Rare Side Effects

  • Allergic reactions: rash, pruritus, or angioedema.
  • Hepatic dysfunction: elevated liver enzymes.
  • Severe dizziness or vertigo.
  • Persistent vomiting.
  • Anaphylaxis: rare but life‑threatening hypersensitivity.

Precautions & Warnings

When considering levodropropizine therapy, several safety measures should be observed.

  • Pregnancy: consult a healthcare professional before use; safety data are limited.
  • Breastfeeding: discuss potential risks with a physician, as drug may pass into milk.
  • Hepatic impairment: use with caution; monitor liver function if indicated.
  • Concomitant CNS depressants: avoid unnecessary combination as additive effects are unlikely but caution is advised.
  • Pediatric use: dosage and safety must be determined by a pediatrician.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodropropizine may interact with other medicines; awareness of potential interactions helps ensure safe use.

Major Interactions (Avoid)

  • CYP450 inhibitors: may increase plasma levels, raising risk of adverse effects.
  • Strong anticholinergic agents: could exacerbate dry mouth.

Moderate Interactions (Monitor Closely)

  • Other antitussives: additive cough suppression may lead to excessive suppression.
  • Sedatives or hypnotics: monitor for enhanced dizziness.
  • NSAIDs: watch for gastrointestinal discomfort when combined.

Frequently Asked Questions

Levotuss Tosse contains levodropropizine, a peripheral antitussive indicated to suppress cough reflexes in conditions such as acute, chronic and non‑productive cough. It helps reduce the frequency and severity of coughing episodes, improving patient comfort during respiratory irritation.

Levodropropizine acts on sensory C‑fibers in the respiratory tract, blocking the transmission of irritation signals to the brainstem cough centre. By inhibiting these peripheral pathways, it lowers cough reflex sensitivity without depressing the central nervous system.

The appropriate dose of Levotuss Tosse is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and local prescribing guidelines. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for levodropropizine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Levotuss Tosse.

To order Levotuss Tosse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Unlike centrally acting antitussives such as codeine, levodropropizine works peripherally, offering cough relief without the risk of sedation or dependence. This makes it a suitable alternative for patients who need cough control but must avoid central nervous system effects.

Levotuss Tosse should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Levotuss Tosse is administered orally. The exact dosage form (tablet, syrup, etc.) is defined by the manufacturer, and patients should take the medication exactly as prescribed, typically with or without food as directed by their healthcare professional.

Serious but rare risks include allergic reactions such as rash, pruritus, angioedema, or anaphylaxis, as well as hepatic dysfunction indicated by elevated liver enzymes. Patients experiencing any signs of severe hypersensitivity or liver injury should seek immediate medical attention.

Levotuss Tosse is contraindicated in individuals with known hypersensitivity to levodropropizine or any excipients in the formulation. Patients with severe hepatic impairment or those taking prohibited concomitant medications should avoid use unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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