Product image of Levovent (Formoterol Fumarate) supplied by GNH India

Levovent

Active Ingredient:
Formoterol Fumarate
Origin:
EU

Levovent (Formoterol Fumarate)

Formoterol fumarate, the active ingredient in Levovent, is a long‑acting β2‑adrenergic agonist (LABA) presented as an inhalation product for inhalation use. It provides bronchodilation to help manage asthma and chronic obstructive pulmonary disease (COPD) in adults.

GNH India supplies Levovent as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide, adhering to stringent quality standards and regulatory requirements. The company ensures reliable logistics and regulatory support for cross‑border distribution. Customers benefit from competitive pricing, transparent communication, and on‑time delivery.

Manufacturer / TM Owner

Genetic Spa

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Indications & Clinical Uses

Formoterol fumarate is a long‑acting β2‑adrenergic agonist used in the management of airway diseases.

  • Asthma: improves airway patency and reduces symptoms such as wheeze, shortness of breath and nighttime awakenings.
  • Chronic obstructive pulmonary disease (COPD): provides sustained bronchodilation to ease breathing during daily activities and reduce exacerbations.
  • Exercise‑induced bronchoconstriction (as adjunct therapy): helps maintain airway openness during physical activity when combined with other controller medications.

How It Works

  • Formoterol fumarate selectively binds to β2‑adrenergic receptors on airway smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic AMP. The rise in cAMP leads to protein kinase A activation, which phosphorylates target proteins causing relaxation of smooth‑muscle fibers and inhibition of mediator release, resulting in prolonged bronchodilation lasting up to 12 hours. This effect provides maintenance control of bronchospasm without the rapid onset required for rescue therapy.

Side Effects

Formoterol fumarate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tremor: mild shaking of the hands or limbs.
  • Headache: transient cranial pain.
  • Throat irritation: discomfort or dryness in the throat.
  • Cough: occasional irritation leading to coughing after inhalation.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing difficulty.
  • Cardiac arrhythmias: irregular heart rhythm, palpitations or tachycardia.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

When prescribing or dispensing Levovent, several precautionary measures should be observed to ensure safe use.

  • Assess cardiovascular status: evaluate for arrhythmias, ischemic heart disease, or uncontrolled hypertension before initiating therapy.
  • Review concomitant β‑blocker use: β‑blockers may diminish bronchodilator response and increase risk of bronchospasm.
  • Monitor for hypokalemia: especially in patients receiving diuretics or high‑dose corticosteroids.
  • Educate on proper inhaler technique: incorrect use can reduce drug delivery and increase local irritation.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Formoterol fumarate can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Beta‑blockers: may antagonize bronchodilation and precipitate bronchospasm.
  • Diuretics: can potentiate hypokalemia, increasing risk of cardiac events.
  • Other long‑acting β2‑agonists: concurrent use raises the likelihood of serious side effects.

Moderate Interactions (Monitor Closely)

  • Inhaled corticosteroids: combined use may increase risk of pneumonia in COPD patients.
  • Theophylline: may raise serum theophylline levels, requiring monitoring.
  • Anticholinergic bronchodilators: additive bronchodilation may cause tachycardia or tremor.

Frequently Asked Questions

Levovent contains formoterol fumarate, a long‑acting β2‑adrenergic agonist that is prescribed for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It helps keep the airways open over a 12‑hour period, reducing symptoms such as wheezing, shortness of breath, and exercise‑induced bronchoconstriction.

Formoterol fumarate works by selectively stimulating β2‑adrenergic receptors on airway smooth‑muscle cells. This activation increases cyclic AMP levels, leading to relaxation of the smooth muscle and inhibition of inflammatory mediator release, which together produce a sustained bronchodilatory effect.

The dose of Levovent is individualized by the prescribing healthcare professional based on the patient’s condition, severity, and response to therapy. The prescriber determines the appropriate inhalation frequency and strength, and patients should follow the specific instructions provided on the prescription label.

Safety data for formoterol fumarate during pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Levovent with their physician before starting treatment.

To order Levovent, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any temperature‑controlled requirements) and the necessary import documentation.

Levovent (formoterol) offers a rapid onset of action within minutes and a duration of up to 12 hours, similar to other long‑acting β2‑agonists such as salmeterol. Compared with short‑acting bronchodilators, it provides sustained control but is not intended for acute symptom relief. Combination inhalers that pair a LABA with an inhaled corticosteroid are often used for step‑up therapy in asthma and COPD.

Levovent should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and heat. Keep the inhaler device upright and avoid exposing it to direct sunlight. Do not freeze the product, and replace the inhaler after the recommended number of doses or when the dose counter indicates it is empty.

Levovent is delivered via an inhalation device. The patient should exhale fully, place the mouthpiece in the mouth, and inhale slowly and deeply while actuating the device as instructed. After inhalation, the patient should hold their breath for a few seconds to allow optimal drug deposition, then breathe out gently. Proper technique should be reviewed by a healthcare professional.

Serious risks associated with Levovent include paradoxical bronchospasm, which can cause sudden worsening of breathing, and cardiac arrhythmias such as tachycardia or palpitations. Rarely, severe allergic reactions (anaphylaxis) may occur. Patients should seek immediate medical attention if they experience sudden breathlessness, chest pain, irregular heartbeat, or signs of an allergic reaction.

Levovent should be avoided in individuals with known hypersensitivity to formoterol fumarate or any component of the inhaler. It is also contraindicated in patients who have experienced a severe paradoxical bronchospasm with a β2‑agonist. Caution is advised for patients with uncontrolled cardiovascular disease, and the drug should be used only under medical supervision in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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