Product image of Levoxacin (Levofloxacin) supplied by GNH India

Levoxacin

Active Ingredient:
Levofloxacin
Origin:
EU

Levoxacin (Levofloxacin)

Levofloxacin, the active ingredient in Levoxacin, is a Fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections in adults and pediatric patients as determined by a prescriber. The drug targets susceptible Gram‑negative and Gram‑positive organisms, providing an option for community‑acquired respiratory infections, urinary tract infections, and skin infections.

GNH India supplies Levoxacin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance and reliable delivery across global markets.

Manufacturer / TM Owner

Sapiens Pharmaceuticals Ltd

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Indications & Clinical Uses

  • Levofloxacin is indicated for several bacterial infections affecting the respiratory, urinary and skin systems.
  • Community‑acquired pneumonia: effective in eradicating the causative pathogens and improving clinical outcomes.
  • Acute bacterial sinusitis: reduces symptoms and bacterial load in the sinuses.
  • Acute exacerbation of chronic bronchitis: shortens duration of infection and improves lung function.
  • Complicated urinary tract infections: eliminates resistant Gram‑negative organisms.
  • Skin and soft tissue infections: treats a broad range of bacterial skin infections.

How It Works

  • Levofloxacin exerts its antibacterial effect by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This inhibition leads to the disruption of bacterial DNA processes, resulting in rapid bactericidal activity against a wide spectrum of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset occurring in many patients.
  • Diarrhea: loose stools that are usually self‑limiting.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional sensation of light‑headedness.
  • Photosensitivity: increased skin sensitivity to sunlight.
  • Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Tendon rupture: especially of the Achilles tendon, potentially leading to loss of function.
  • QT‑interval prolongation: may precipitate cardiac arrhythmias.
  • Severe allergic reactions: including anaphylaxis and Stevens‑Johnson syndrome.
  • Clostridioides difficile infection: severe colitis requiring medical attention.
  • Peripheral neuropathy: persistent nerve pain or tingling.
  • Hepatotoxicity: elevated liver enzymes indicating liver injury.

Precautions & Warnings

  • When prescribing levofloxacin, clinicians should consider several safety precautions.
  • Renal impairment: adjust dose based on creatinine clearance.
  • History of tendon disorders: avoid use due to risk of tendon rupture.
  • Prolonged QT interval: monitor cardiac rhythm.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Concurrent use with NSAIDs: increased risk of central nervous system effects.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levofloxacin can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Drugs that prolong QT interval (e.g., quinidine, amiodarone): increase risk of cardiac arrhythmia.
  • Warfarin: may enhance anticoagulant effect and increase bleeding risk.
  • Other fluoroquinolones: additive toxicity, avoid concurrent use.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened central nervous system adverse effects.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: combined use raises tendon rupture risk.
  • Cyclosporine: may increase levofloxacin serum concentrations.
  • Theophylline: possible elevation of theophylline levels leading to toxicity.
  • Oral contraceptives: may reduce contraceptive efficacy.
  • Diabetic agents: heightened risk of hypoglycemia.

Frequently Asked Questions

Levoxacin contains levofloxacin, a fluoroquinolone antibiotic used to treat bacterial infections such as pneumonia, sinusitis, acute exacerbations of chronic bronchitis, complicated urinary tract infections, and skin and soft‑tissue infections, as prescribed by a qualified healthcare professional.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. This blockade leads to bacterial cell death, providing a bactericidal effect against a broad spectrum of Gram‑negative and Gram‑positive organisms.

The dosage of Levoxacin is determined by the prescribing clinician based on the specific infection, patient age, renal function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare provider.

Safety of levofloxacin during pregnancy or lactation has not been definitively established. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Levoxacin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other fluoroquinolones, levofloxacin offers once‑daily dosing for many indications and a broad spectrum of activity. It is often preferred for respiratory infections due to its high lung tissue penetration, but selection should consider local resistance patterns and patient‑specific factors.

Store Levoxacin at below 25 °C in a dry place, keeping the tablets in the original container to protect them from moisture and light. Do not store in a refrigerator or expose to excessive heat.

Levoxacin is taken orally, usually with a full glass of water. It may be taken with or without food, but antacids containing magnesium or aluminum should be spaced at least two hours apart to avoid reduced absorption.

Serious adverse events include tendon rupture, especially in the Achilles tendon, QT‑interval prolongation leading to cardiac arrhythmias, severe hypersensitivity reactions, and Clostridioides difficile‑associated diarrhea. Patients should seek immediate medical attention if they experience sudden joint pain, palpitations, severe rash, or persistent diarrhea.

Levoxacin should be avoided in individuals with known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with uncontrolled QT prolongation, and in situations where safer alternative antibiotics are available, unless specifically indicated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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