Product image of Lexacin (Levofloxacin Hemihydrate) supplied by GNH India

Lexacin

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Lexacin (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Lexacin, is a fluoroquinolone antibiotic presented as an injection for intravenous use. It treats community‑acquired pneumonia, complicated urinary tract infections, skin and soft tissue infections, and septicemia in adult patients.

GNH India supplies Lexacin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Verisfield S.M.S.A

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibacterial indicated for several serious bacterial infections.

  • Community‑acquired pneumonia: achieves bacterial eradication and clinical cure in adult patients.
  • Complicated urinary tract infections: eliminates causative pathogens and resolves infection.
  • Skin and soft tissue infections: clears infection and promotes healing of affected tissues.
  • Septicemia: provides rapid bacterial clearance in systemic infection.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By blocking these targets, the drug prevents bacterial cell division and leads to bacterial cell death, offering a bactericidal effect against a broad spectrum of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: often self‑limiting watery stools.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional vertiginous sensations.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur without warning.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile‑associated diarrhea: potentially life‑threatening colitis.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Peripheral neuropathy: sensory disturbances or weakness.

Precautions & Warnings

Levofloxacin requires careful assessment of patient risk factors before use.

  • Renal impairment: adjust dose or monitor renal function closely.
  • History of tendon disorders: avoid use or monitor for tendon pain.
  • QT prolongation risk: avoid in patients with known cardiac arrhythmias.
  • Concurrent use of NSAIDs: increased risk of central nervous system stimulation.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Levofloxacin can interact with several medicines, affecting safety or efficacy.

Major Interactions (Avoid)

  • Ciprofloxacin: additive QT prolongation risk.
  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Theophylline: can raise serum theophylline concentrations.
  • Cyclosporine: heightened risk of neurotoxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: increased chance of central nervous system stimulation.
  • Diabetes medications (e.g., insulin): may affect glucose control.
  • Corticosteroids: elevated risk of tendon rupture.

Frequently Asked Questions

Lexacin, containing levofloxacin, is indicated for serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft tissue infections, and septicemia. It is administered intravenously to achieve rapid bacterial clearance in these conditions.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug prevents bacterial cell division, leading to a bactericidal effect against a broad range of Gram‑negative and Gram‑positive organisms.

The dosage of Lexacin is determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and other clinical factors. Healthcare professionals set the appropriate dose and infusion rate for each individual case.

Levofloxacin is classified as a pregnancy‑category unknown drug. It should be used during pregnancy or lactation only when the potential benefits justify the potential risks to the fetus or infant. Clinicians must evaluate each situation carefully.

To order Lexacin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Lexacin (levofloxacin) offers a broad spectrum of activity and is often preferred for its once‑daily dosing and strong activity against both Gram‑negative and Gram‑positive pathogens. Compared with older fluoroquinolones, levofloxacin may have a more favorable safety profile, but all agents share class‑related risks such as tendon injury and QT prolongation.

Lexacin should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Maintaining the cold‑chain ensures the stability and potency of the injectable formulation.

Lexacin is supplied as an intravenous injection. It is administered by a healthcare professional through a peripheral or central vein, typically over a set infusion period as directed by the prescriber. Proper aseptic technique and infusion equipment are required.

Serious risks include tendon rupture (especially Achilles), QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, hepatic toxicity, and peripheral neuropathy. Patients should be monitored closely for any of these events.

Lexacin is contraindicated in patients with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is advised for individuals with a history of tendon disorders, significant cardiac arrhythmias, or those taking medications that prolong the QT interval.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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