Product image of Lexavon (Levofloxacin Hemihydrate) supplied by GNH India

Lexavon

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Lexavon (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Lexavon, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial eye infections such as conjunctivitis, keratitis and post‑operative infections in adults and children.

GNH India supplies Lexavon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Levofloxacin ophthalmic drops act on bacterial pathogens that cause eye infections. They are indicated for:

  • Bacterial conjunctivitis: reduces redness, discharge and bacterial load in the conjunctiva.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Post‑operative ocular infection: prevents or treats infection after eye surgery, supporting recovery.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division and leads to bacterial death, providing a bactericidal effect against susceptible ocular pathogens.

Side Effects

Levofloxacin ophthalmic solution may cause local and systemic adverse reactions.

Common Side Effects

  • Ocular irritation: mild burning or stinging on instillation.
  • Redness: transient conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Blurred vision: temporary visual disturbance.
  • Foreign body sensation: feeling of grit in the eye.
  • Mild headache: occasional peri‑ocular discomfort.

Serious or Rare Side Effects

  • Allergic reaction: swelling, rash or hives around the eye.
  • Stevens‑Johnson syndrome: severe mucocutaneous blistering.
  • Corneal ulceration: worsening of corneal lesions.
  • Severe eye pain: persistent or worsening discomfort.
  • Vision loss: sudden decrease in visual acuity.
  • Systemic hypersensitivity: fever, chills or joint pain.

Precautions & Warnings

Levofloxacin ophthalmic drops require careful use to minimise risks.

  • Allergy assessment: confirm no known hypersensitivity to fluoroquinolones.
  • Age considerations: use with caution in pediatric patients; safety data are limited.
  • Contact lens wearers: avoid lens use until treatment is completed and the eye is clear.
  • Systemic absorption: monitor for systemic fluoroquinolone effects during prolonged therapy.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Levofloxacin ophthalmic solution can interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon rupture.
  • Corticosteroid eye drops: may reduce antimicrobial efficacy and delay healing.
  • Anticholinergic agents: may exacerbate ocular dryness.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: monitor for delayed corneal healing.
  • Herbal supplements containing quinine: may increase systemic exposure.
  • High‑dose vitamin C: may affect ocular drug absorption.

Frequently Asked Questions

Lexavon is a prescription ophthalmic solution containing levofloxacin. It is used to treat bacterial eye infections such as conjunctivitis, keratitis and infections that can occur after eye surgery. The medication works locally in the eye to eliminate susceptible bacteria and promote healing.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug stops bacterial cell division, leading to bacterial death. This bactericidal action reduces the infection load on the ocular surface.

The dosing regimen for Lexavon is determined by the prescribing clinician based on the specific infection, severity and patient factors. The prescriber will specify the number of drops, frequency and duration of therapy on the prescription label.

Safety of levofloxacin ophthalmic use in pregnancy or while breastfeeding has not been established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Lexavon, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lexavon (levofloxacin) belongs to the fluoroquinolone class, offering broad‑spectrum coverage against Gram‑negative and Gram‑positive ocular pathogens. Compared with older agents such as ciprofloxacin, levofloxacin often provides higher potency with once‑daily dosing options, though choice depends on local resistance patterns and physician preference.

Lexavon should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct sunlight and moisture, and discard any solution that appears discolored or cloudy.

Lexavon is applied as eye drops. The prescribed number of drops is placed into the conjunctival sac of the affected eye(s) at the intervals indicated by the prescriber, typically without touching the tip of the bottle to the eye or surrounding tissues.

Serious risks, although rare, include severe allergic reactions such as Stevens‑Johnson syndrome, corneal ulceration, significant vision loss and systemic hypersensitivity reactions. Patients should seek immediate medical attention if they experience worsening eye pain, swelling, rash or any signs of an allergic response.

Lexavon should not be used by individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It is also contraindicated in patients where the risk of tendon rupture or severe systemic fluoroquinolone effects outweighs the therapeutic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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