Product image of Lexavon (Levofloxacin Hemihydrate) supplied by GNH India

Lexavon

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Lexavon (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Lexavon, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial infections of the eye such as conjunctivitis, keratitis and blepharitis in patients requiring prescription therapy.

GNH India supplies Lexavon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Lexavon, a fluoroquinolone ophthalmic antibiotic, is indicated for bacterial infections of the ocular surface.

  • Bacterial conjunctivitis: reduces bacterial load and promotes resolution of conjunctival infection.
  • Bacterial keratitis: eradicates pathogenic bacteria to prevent corneal damage.
  • Blepharitis: controls bacterial overgrowth on the eyelid margin, improving inflammation and symptoms.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these targets, it prevents bacterial cell division and leads to bacterial cell death, providing a bactericidal effect against susceptible ocular pathogens.

Side Effects

Adverse reactions may occur with ocular administration of Lexavon.

Common Side Effects

  • Eye irritation: transient burning or stinging sensation.
  • Redness: mild conjunctival hyperemia.
  • Foreign body sensation: feeling of grit in the eye.
  • Blurred vision: temporary visual disturbance.
  • Tearing: increased lacrimation.
  • Photophobia: sensitivity to light.

Serious or Rare Side Effects

  • Corneal ulceration: progressive corneal damage requiring immediate attention.
  • Allergic reaction: swelling, rash, or severe itching of the eye.
  • Stevens‑Johnson syndrome: rare systemic hypersensitivity with mucosal involvement.
  • Severe ocular inflammation: marked swelling or pain indicating possible infection progression.

Precautions & Warnings

Lexavon should be used with caution and according to professional guidance.

  • Hypersensitivity: avoid in patients with known allergy to fluoroquinolones.
  • Contact lenses: do not wear lenses during treatment unless advised.
  • Infection monitoring: discontinue if condition worsens or new symptoms appear.
  • Prescription use: follow the prescriber's instructions precisely.
  • Storage: Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lexavon may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: increased risk of tendon toxicity.
  • Corticosteroid eye drops: may mask signs of infection.
  • Live vaccines: potential reduction in vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: possible pupil size alteration.
  • NSAID eye drops: additive ocular irritation.
  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.

Frequently Asked Questions

Lexavon is a prescription ophthalmic solution containing levofloxacin, a fluoroquinolone antibiotic. It is used to treat bacterial infections of the eye, specifically bacterial conjunctivitis, bacterial keratitis, and blepharitis, by eliminating the causative microorganisms and helping to restore ocular health.

Levofloxacin works by binding to bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication and transcription. Inhibiting these enzymes stops bacterial cell division, leading to bacterial death and clearance of the infection in the treated eye.

The dosage and frequency of Lexavon are determined by the prescribing clinician based on the specific infection, severity, and patient factors. The prescriber will provide detailed instructions on how many drops to instill and how often they should be applied.

Safety of levofloxacin ophthalmic use during pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by the treating physician.

To order Lexavon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lexavon (levofloxacin) offers broad‑spectrum coverage against Gram‑positive and Gram‑negative ocular pathogens and has a favorable penetration profile in corneal tissue. Compared with older agents such as ciprofloxacin, levofloxacin often requires fewer daily administrations and may have a lower risk of resistance development.

Lexavon should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed when not in use and retain it in its original packaging to protect the solution from contamination.

Lexavon is applied as eye drops directly onto the affected eye(s) according to the prescriber's directions. Typically, the patient tilts the head back, pulls down the lower eyelid to create a pocket, instills the prescribed number of drops, and gently closes the eye for a few seconds. Contact lenses should be removed unless otherwise instructed.

Serious adverse events, although rare, include corneal ulceration, severe allergic reactions such as swelling or rash, and systemic hypersensitivity syndromes like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience worsening pain, vision changes, or signs of a severe reaction.

Lexavon should not be used by individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It is also contraindicated in patients with active viral or fungal eye infections, as the drug does not treat these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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