Product image of Liaflox (Ofloxacin) supplied by GNH India

Liaflox

Active Ingredient:
Ofloxacin
Origin:
EU

Liaflox (Ofloxacin)

Ofloxacin, the active ingredient in Liaflox, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial infections of the eye, such as conjunctivitis and keratitis, in adult and pediatric patients as prescribed by a qualified clinician.

GNH India supplies Liaflox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for importers. Its global logistics network ensures timely delivery to diverse healthcare settings.

Manufacturer / TM Owner

Genetic Spa

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Indications & Clinical Uses

Ofloxacin ophthalmic solution is indicated for bacterial eye infections, targeting the ocular surface and corneal tissues.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of redness, discharge, and irritation.
  • Bacterial keratitis: eradicates causative organisms and promotes healing of corneal ulcers.
  • Other ocular bacterial infections: treats infection of the eyelid margin, lacrimal sac, or postoperative ocular sites.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, the drug prevents DNA synthesis and transcription, leading to bacterial cell death. This mechanism is concentration‑dependent and remains effective in the aqueous humor when administered as an eye drop.

Side Effects

Ophthalmic ofloxacin may cause local and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

  • Stinging or burning on instillation.
  • Temporary blurred vision.
  • Redness of the conjunctiva.

Serious or Rare Side Effects

  • Corneal ulceration or perforation.
  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Tendon rupture or systemic tendonitis.

Precautions & Warnings

When prescribing ophthalmic ofloxacin, clinicians should consider several precautionary measures to minimize risk.

  • Assess patient history: exclude known hypersensitivity to fluoroquinolones.
  • Use with caution in patients with corneal epithelial defects.
  • Avoid concomitant use with other topical ocular antibiotics unless directed.
  • Monitor for signs of tendon pain or systemic fluoroquinolone reactions.
  • Advise patients to report severe eye pain, vision changes, or allergic symptoms promptly.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Ofloxacin ophthalmic solution can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon toxicity.
  • Anticholinergic eye drops (e.g., atropine): may reduce ocular absorption.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may increase risk of corneal irritation.
  • Corticosteroid eye preparations: may mask signs of infection.
  • Oral antacids containing magnesium or aluminum: can affect systemic absorption if oral fluoroquinolone is also used.

Frequently Asked Questions

Liaflox is an ophthalmic formulation of ofloxacin indicated for the treatment of bacterial infections of the eye, including bacterial conjunctivitis, bacterial keratitis, and other ocular bacterial infections as determined by a qualified healthcare professional.

Ofloxacin belongs to the fluoroquinolone class and works by inhibiting bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for DNA replication and transcription; their inhibition leads to bacterial cell death and eradication of the infection.

The specific dosing regimen for Liaflox is set by the prescribing clinician based on the severity of the infection, patient age, and response to therapy. The prescriber determines the number of drops, frequency, and duration of treatment.

Safety data for ophthalmic ofloxacin in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Prescribers should weigh potential benefits against risks and consider alternative treatments when appropriate.

To order Liaflox, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Liaflox (ofloxacin) offers broad‑spectrum activity against Gram‑negative and Gram‑positive ocular pathogens, similar to other fluoroquinolone eye drops such as ciprofloxacin. Compared with older agents like chloramphenicol, ofloxacin generally provides higher potency and a lower risk of bacterial resistance, though choice depends on local susceptibility patterns and patient factors.

Liaflox should be stored below 25 °C in its original container, protected from light and moisture. Do not freeze the product. Keep the vial tightly closed when not in use and discard any solution that appears discolored or contaminated.

Liaflox is applied as eye drops directly onto the affected eye(s). The patient should wash hands before use, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops. The eye should be gently closed for a few seconds to allow absorption.

Serious adverse reactions include corneal ulceration or perforation, severe allergic responses such as angioedema or anaphylaxis, and systemic tendon toxicity (e.g., tendon rupture). Patients should be instructed to seek immediate medical attention if they experience intense eye pain, sudden vision loss, or signs of an allergic reaction.

Liaflox should not be used by individuals with a known hypersensitivity to ofloxacin, other fluoroquinolones, or any component of the formulation. Caution is also advised for patients with a history of tendon disorders, severe corneal disease, or those taking systemic fluoroquinolones concurrently.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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