Product image of Libeli (Chlormadinone Acetate, Ethinylestradiol) supplied by GNH India

Libeli

Active Ingredient:
Chlormadinone Acetate, Ethinylestradiol
Origin:
EU

Libeli (Chlormadinone Acetate, Ethinylestradiol)

Chlormadinone acetate, the active ingredient in Libeli, is a combined oral contraceptive presented as an oral tablet for oral use. It is employed to prevent pregnancy and to regulate menstrual cycles in women of reproductive age. The formulation also contains ethinylestradiol, an estrogen component that works synergistically with the progestin to provide reliable contraception and cycle control.

GNH India supplies Libeli as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Libeli, a combined oral contraceptive, is used in hormonal management of reproductive health.

  • Contraception: provides reliable prevention of pregnancy by inhibiting ovulation and altering cervical mucus.
  • Menstrual cycle regulation: helps achieve more predictable bleeding patterns and reduces dysmenorrhea.
  • Prevention of functional ovarian cysts: reduces the formation of cysts associated with the menstrual cycle.

How It Works

  • Libeli combines a progestogenic agent (chlormadinone acetate) with an estrogen (ethinylestradiol). The progestin suppresses the hypothalamic‑pituitary‑ovarian axis, preventing the mid‑cycle surge of luteinising hormone and thereby inhibiting ovulation. Ethinylestradiol stabilises the endometrium and enhances the progestin's effect on cervical mucus, creating a hostile environment for sperm and reducing the likelihood of implantation.

Side Effects

Libeli may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort of the breasts.
  • Spotting: irregular light bleeding between periods.

Serious or Rare Side Effects

  • Deep vein thrombosis: formation of blood clots in deep veins.
  • Pulmonary embolism: clot migration to the lungs.
  • Stroke: cerebrovascular accident due to clotting or hemorrhage.

Precautions & Warnings

Before prescribing Libeli, clinicians should consider several precautionary measures to ensure safe use.

  • Assess thrombotic risk: avoid in women with a history of clotting disorders.
  • Screen for hypertension: monitor blood pressure regularly during therapy.
  • Consider smoking status: contraindicated in women over 35 who smoke.
  • Review hepatic function: use with caution in patients with liver disease.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Libeli can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin): markedly reduce contraceptive effectiveness.
  • Anticoagulants (e.g., warfarin): may increase risk of thrombotic events.
  • Antiepileptics (e.g., carbamazepine): decrease hormone levels, compromising contraception.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly lower absorption of hormones.
  • Herbal supplements (e.g., St. John’s wort): can reduce plasma concentrations of ethinylestradiol.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): may enhance mood‑related side effects.

Frequently Asked Questions

Libeli is a combined oral contraceptive that is prescribed to prevent pregnancy and to help regulate menstrual cycles in women of reproductive age. It works by inhibiting ovulation and modifying cervical mucus and the endometrium to reduce the chance of fertilisation and implantation.

Chlormadinone acetate is a progestin that suppresses the hypothalamic‑pituitary‑ovarian axis, preventing the luteinising hormone surge that triggers ovulation. Together with the estrogen ethinylestradiol, it also thickens cervical mucus and stabilises the endometrium, creating conditions that are unfavorable for sperm penetration and implantation.

The specific dosing regimen for Libeli is determined by the prescribing clinician based on the product’s labeling and the patient’s individual needs. Healthcare professionals select the appropriate tablet strength, schedule, and duration in accordance with local regulatory guidance.

Libeli is intended for use as a contraceptive and should not be taken during pregnancy. If pregnancy occurs, the medication should be discontinued. Limited data are available for breastfeeding; clinicians usually advise caution and may recommend alternative contraception while nursing.

To request Libeli, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Libeli contains chlormadinone acetate and ethinylestradiol, a progestin‑estrogen pairing similar to many other combined pills. Compared with alternatives, chlormadinone acetate offers a distinct progestogenic profile that may influence side‑effect patterns such as acne or lipid changes, but overall contraceptive efficacy is comparable when taken correctly.

Libeli tablets should be stored at ambient temperature, below 25 °C, in the original container. Keep them away from moisture, direct sunlight and excessive heat to maintain product stability throughout its shelf life.

Libeli is taken orally, usually once daily at the same time each day, following the regimen specified on the product label. The tablets are swallowed whole with water and should be started according to the prescribing information, often on the first day of the menstrual period.

Serious but rare risks include venous thromboembolism such as deep‑vein thrombosis, pulmonary embolism, stroke and myocardial infarction. Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should be evaluated carefully before initiating therapy.

Libeli is contraindicated in women with known or suspected pregnancy, active or history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or in those over 35 who smoke. It should also be avoided in individuals with known hypersensitivity to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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