Product image of Liberelle (Ethinylestradiol, Norgestimate) supplied by GNH India

Liberelle

Active Ingredient:
Ethinylestradiol, Norgestimate
Origin:
EU

Liberelle (Ethinylestradiol, Norgestimate)

Ethinylestradiol, the active ingredient in Liberelle, is a combined oral contraceptive presented as an oral tablet for oral use. It prevents pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus and endometrial lining.
GNH India supplies Liberelle as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Exeltis Healthcare S.L

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Indications & Clinical Uses

Liberelle, a combined oral contraceptive, is used to prevent unintended pregnancy.

  • Prevention of pregnancy: provides reliable contraception for women of childbearing potential.

How It Works

  • Liberelle contains ethinylestradiol and norgestimate, which suppress the hypothalamic‑pituitary‑gonadal axis, preventing the mid‑cycle surge of luteinizing hormone and thereby inhibiting ovulation. The estrogen component stabilises the endometrium, while the progestogen thickens cervical mucus and induces endometrial changes that reduce the likelihood of fertilisation and implantation.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Nausea: mild stomach upset, especially when starting therapy.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: temporary swelling or discomfort.
  • Spotting or breakthrough bleeding: irregular bleeding during the first cycles.
  • Mood changes: irritability or mild mood swings.
  • Weight fluctuation: slight fluid retention or appetite changes.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism.
  • Arterial thrombosis: stroke or myocardial infarction.
  • Hypertension: significant increase in blood pressure.
  • Liver dysfunction: jaundice or abnormal liver enzymes.
  • Gallbladder disease: gallstones or cholecystitis.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before using Liberelle, consider the following precautions.

  • Smoking: avoid if over 35 years old, as risk of cardiovascular events increases.
  • Cardiovascular disease: contraindicated in patients with history of thromboembolism, stroke, or myocardial infarction.
  • Liver disease: use with caution in patients with active liver disease or impaired function.
  • Migraine with aura: contraindicated due to elevated stroke risk.
  • Breast cancer: avoid in current or past estrogen‑dependent malignancies.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Liberelle may interact with several medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Antiepileptic drugs (e.g., carbamazepine, phenytoin): reduce contraceptive efficacy.
  • Rifampin and other potent enzyme inducers: markedly decrease hormone levels.
  • Certain HIV protease inhibitors: may increase hormone concentrations.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., ketoconazole): may increase hormone levels.
  • St. John’s wort: may lower contraceptive effectiveness.
  • Certain antibiotics (e.g., tetracycline): occasional reduction in efficacy, monitor for breakthrough bleeding.

Frequently Asked Questions

Liberelle is a combined oral contraceptive containing ethinylestradiol and norgestimate. It is prescribed to prevent unintended pregnancy in women of reproductive age by inhibiting ovulation and creating cervical mucus changes that reduce fertilisation.

Ethinylestradiol, the estrogen component, suppresses the hypothalamic‑pituitary‑gonadal axis, preventing the luteinizing hormone surge needed for ovulation. It also stabilises the endometrium, contributing to the contraceptive effect.

The dosing regimen for Liberelle is determined by the prescribing healthcare professional. Typically, it is taken as a daily oral tablet according to the prescribed cycle, but the exact schedule should follow the prescriber’s instructions.

Liberelle is classified as pregnancy category X, meaning it must not be used during pregnancy because it can harm the fetus. It is also not recommended while breastfeeding, as hormones may pass into breast milk and affect the infant.

To order Liberelle, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Liberelle contains ethinylestradiol and norgestimate, a progestogen with a favorable bleeding profile and lower androgenic activity compared with some older progestins. This may result in fewer acne‑related side effects and more predictable withdrawal bleeding, while offering similar contraceptive efficacy.

Liberelle tablets should be stored at ambient temperature, below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and keep out of reach of children.

Liberelle is taken orally, usually once daily at the same time each day. The tablets are swallowed with water and should be started according to the prescriber’s schedule, often on the first day of the menstrual period.

Serious risks include venous thromboembolism, arterial thrombosis (stroke or myocardial infarction), hypertension, and severe liver disease. Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should avoid this medication.

Liberelle is contraindicated in women who are pregnant, have a history of thromboembolic events, uncontrolled hypertension, active liver disease, known or suspected breast cancer, or migraine with aura. It should also be avoided by smokers over 35 years of age.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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