Product image of Liberostin (Cytisinicline) supplied by GNH India

Liberostin

Active Ingredient:
Cytisinicline
Origin:
EU

Liberostin (Cytisinicline)

Cytisinicline, the active ingredient in Liberostin, is a nicotinic acetylcholine receptor partial agonist presented as an oral formulation for oral use. It is used to aid smoking cessation in adult smokers.

GNH India supplies Liberostin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aflofarm Farmacja Polska Sp. Z O.O.

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Indications & Clinical Uses

Liberostin is a nicotinic acetylcholine receptor partial agonist indicated for smoking‑related disorders.

  • Smoking cessation: helps adult smokers reduce nicotine withdrawal symptoms and increase the likelihood of quitting.
  • Tobacco dependence: supports individuals attempting to discontinue regular tobacco use.
  • Nicotine addiction: alleviates cravings associated with nicotine dependence.

How It Works

  • Cytisinicline binds to the α4β2 subtype of neuronal nicotinic acetylcholine receptors as a partial agonist. By stimulating these receptors at a lower efficacy than nicotine, it reduces the intensity of withdrawal symptoms while also blocking nicotine from fully activating the receptors, thereby diminishing the reinforcing effects of smoking.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient tension‑type headaches.
  • Insomnia: difficulty falling or staying asleep.
  • Abnormal dreams: vivid or unpleasant dreams.
  • Dry mouth: reduced salivation.
  • Gastrointestinal discomfort: mild abdominal cramping.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Mood changes: depression, anxiety, or irritability.
  • Cardiovascular events: palpitations or increased heart rate.
  • Severe nausea/vomiting: persistent and leading to dehydration.
  • Respiratory distress: wheezing or bronchospasm.
  • Suicidal ideation: thoughts of self‑harm.

Precautions & Warnings

Before initiating Liberostin, consider the following precautions:

  • Cardiovascular assessment: evaluate heart disease history before use.
  • Psychiatric monitoring: watch for mood alterations or depressive symptoms.
  • Liver function: adjust use in patients with severe hepatic impairment.
  • Pregnancy and lactation: discuss potential risks with a healthcare professional.
  • Concomitant nicotine products: avoid using other nicotine replacement therapies simultaneously.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Potential drug interactions should be reviewed prior to therapy.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may increase risk of hypertensive crisis.
  • Other nicotine replacement products: can lead to excessive nicotinic stimulation.
  • Certain antidepressants (e.g., bupropion): may potentiate central nervous system effects.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may alter plasma levels of Cytisinicline.
  • Alcohol: can exacerbate dizziness or nausea.
  • Antihypertensive agents: monitor blood pressure for additive effects.

Frequently Asked Questions

Liberostin is prescribed to help adult smokers quit tobacco use. It works by reducing nicotine withdrawal symptoms and cravings, thereby supporting smoking cessation efforts as part of a comprehensive quit‑plan.

Cytisinicline acts as a partial agonist at the α4β2 nicotinic acetylcholine receptors in the brain. It provides enough stimulation to lessen withdrawal while blocking nicotine from fully activating the receptors, which reduces the rewarding effects of smoking.

The dosage of Liberostin is individualized by a qualified prescriber based on the patient’s medical history, smoking habits, and response to therapy. Patients should follow the specific instructions provided by their healthcare professional.

Safety data for Cytisinicline in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before starting treatment.

To request Liberostin, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Liberostin (Cytisinicline) is a nicotinic receptor partial agonist, whereas many alternatives such as varenicline act similarly but differ in binding affinity and side‑effect profiles. Compared with nicotine replacement therapy, Liberostin targets central receptors directly, potentially offering a different balance of efficacy and tolerability.

Liberostin should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and extreme heat to maintain stability.

Liberostin is taken orally as directed by a healthcare professional. The tablet or capsule is swallowed whole with water, typically once or twice daily, depending on the prescriber’s regimen.

Serious risks include severe allergic reactions (rash, swelling, breathing difficulty), significant mood changes such as depression or suicidal thoughts, and cardiovascular events like palpitations or increased heart rate. Patients should seek immediate medical attention if any of these occur.

Liberostin is contraindicated in individuals with known hypersensitivity to Cytisinicline or any excipients, those currently using other nicotine replacement products, and patients with uncontrolled severe cardiovascular disease. A physician should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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