Product image of Librax (Chlordiazepoxide, Clidinium Bromide) supplied by GNH India

Librax

Active Ingredient:
Chlordiazepoxide, Clidinium Bromide
Origin:
EU

Librax (Chlordiazepoxide, Clidinium Bromide)

Chlordiazepoxide and Clidinium bromide, the active ingredients in Librax, are a benzodiazepine and an anticholinergic presented as a 5 mg/2.5 mg oral tablet for oral use. They treat anxiety disorders and gastrointestinal spasm in adults.
GNH India supplies Librax as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Librax acts on central nervous system anxiety pathways and gastrointestinal smooth‑muscle tone, providing relief in several conditions.

  • Anxiety disorders: reduces excessive worry and tension.
  • Irritable bowel syndrome: eases abdominal cramping and discomfort.
  • Peptic ulcer disease: diminishes ulcer‑related pain and spasms.
  • Gastrointestinal spasm: relaxes smooth‑muscle contractions in the gut.

How It Works

  • Chlordiazepoxide binds to the GABA‑A receptor complex, enhancing the inhibitory effect of GABA and producing anxiolytic, sedative and muscle‑relaxant actions. Clidinium bromide antagonizes muscarinic acetylcholine receptors in the gastrointestinal tract, decreasing smooth‑muscle tone and secretions, which helps control spasms and ulcer‑related pain.

Side Effects

Librax may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: feeling unusually sleepy.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Constipation: infrequent or hard stools.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing that may require medical attention.
  • Severe hypotension: marked drop in blood pressure.
  • Paradoxical agitation: unexpected increase in anxiety or aggression.
  • Dependence or withdrawal: physical reliance with potential withdrawal symptoms upon cessation.
  • Anaphylaxis: severe allergic reaction with rash, swelling, and breathing difficulty.

Precautions & Warnings

Before prescribing Librax, clinicians should consider several safety factors.

  • Avoid alcohol: concurrent use can intensify sedation and respiratory effects.
  • Use caution in elderly: increased sensitivity to CNS depression and anticholinergic effects.
  • Monitor liver function: both components are metabolised hepatically.
  • Assess substance‑use history: risk of dependence with benzodiazepine component.
  • Pregnancy category D: only if benefits outweigh risks; avoid during breastfeeding.
  • Store at ambient temperature below 25°C: keep in original pack, protect from moisture.

Avoid Interactions

Librax can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression.
  • Opioids: heightened risk of respiratory depression and sedation.
  • Other CNS depressants (e.g., barbiturates, antihistamines): may cause profound sedation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase clidinium levels.
  • Anticholinergic agents (e.g., atropine): can enhance anticholinergic side effects.
  • Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome when combined with benzodiazepines.

Frequently Asked Questions

Librax is prescribed for anxiety disorders, irritable bowel syndrome, peptic ulcer disease and other gastrointestinal spasms. It combines an anxiolytic benzodiazepine with an anticholinergic to address both central nervous system anxiety and smooth‑muscle spasm in the gut.

Chlordiazepoxide enhances the activity of the GABA‑A receptor, increasing inhibitory neurotransmission in the brain. This produces anxiolytic, sedative and muscle‑relaxant effects that help reduce anxiety and associated tension.

The specific dose of Librax is determined by the prescribing clinician based on the individual’s condition, age, weight and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Librax is classified as pregnancy category D, indicating potential risk to the fetus. It should only be used if the therapeutic benefit justifies the risk. The drug is also excreted in breast milk, so breastfeeding mothers should discuss alternatives with their healthcare provider.

To request Librax, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Librax uniquely combines a benzodiazepine with an anticholinergic, offering simultaneous anxiety relief and gastrointestinal spasm control. Alternative regimens may use separate agents, which can increase pill burden and potential drug‑drug interactions. Clinicians choose Librax when a single‑tablet solution aligns with the patient’s therapeutic goals.

Librax tablets should be stored at ambient temperature below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency throughout its shelf life.

Librax is taken orally as a tablet, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless a healthcare professional advises otherwise. Dosing frequency is set by the prescriber.

Serious risks include respiratory depression, severe hypotension, paradoxical agitation, dependence or withdrawal symptoms, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience difficulty breathing, extreme drowsiness, or signs of an allergic response.

Librax is contraindicated in individuals with known hypersensitivity to chlordiazepoxide, clidinium bromide or any component of the formulation, as well as in patients with acute narrow‑angle glaucoma, severe liver impairment, or those currently taking other CNS depressants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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