Product image of Librax (Chlordiazepoxide, Clidinium Bromide) supplied by GNH India

Librax

Active Ingredient:
Chlordiazepoxide, Clidinium Bromide
Origin:
EU

Librax (Chlordiazepoxide, Clidinium Bromide)

Chlordiazepoxide, the active ingredient in Librax, is a benzodiazepine presented as a 5 mg/2.5 mg tablet for oral use. It treats gastrointestinal spasm and associated anxiety in adults with functional gastrointestinal disorders.

GNH India supplies Librax as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

  • Librax combines a benzodiazepine and an anticholinergic to manage functional gastrointestinal disorders and related conditions.
  • Irritable bowel syndrome: reduces abdominal pain and cramping.
  • Peptic ulcer disease: decreases ulcer‑related pain and gastric hypersecretion.
  • Functional gastrointestinal disorders: alleviates smooth‑muscle spasm and associated anxiety.

How It Works

  • Chlordiazepoxide enhances the activity of the GABA‑A receptor complex, producing anxiolysis, muscle relaxation and central sedation. Clidinium bromide is a muscarinic receptor antagonist that blocks acetylcholine‑mediated stimulation of gastrointestinal smooth muscle, reducing spasms and secretions. The combined actions provide symptomatic relief of abdominal pain, cramping and associated anxiety.

Side Effects

Librax may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness or fatigue
  • Dry mouth
  • Constipation
  • Dizziness or light‑headedness
  • Blurred vision

Serious or Rare Side Effects

  • Severe respiratory depression, especially with other CNS depressants
  • Marked hypotension or cardiovascular collapse
  • Paradoxical agitation or severe confusion
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

  • Before prescribing Librax, clinicians should consider several safety factors.
  • Assess anxiety level: evaluate baseline anxiety and dependence risk.
  • Monitor for dependence: benzodiazepine component may lead to tolerance with prolonged use.
  • Avoid in narrow‑angle glaucoma: anticholinergic effect can worsen intra‑ocular pressure.
  • Caution in elderly: increased susceptibility to sedation, falls and confusion.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Librax can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other CNS depressants (e.g., barbiturates, sedative antihistamines): may cause profound sedation.
  • Alcohol: potentiates sedative and respiratory‑depressant effects.
  • Opioids: increased risk of respiratory depression and profound CNS depression.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs (e.g., antihistamines, tricyclic antidepressants): additive dry mouth, constipation, urinary retention.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise chlordiazepoxide plasma levels.
  • Antihistamines: enhanced anticholinergic burden leading to confusion in susceptible patients.

Frequently Asked Questions

Librax is prescribed to relieve abdominal pain, cramping and related anxiety in conditions such as irritable bowel syndrome, peptic ulcer disease and other functional gastrointestinal disorders. The combination of a benzodiazepine and an anticholinergic targets both muscle spasm and central nervous system factors that contribute to discomfort.

Chlordiazepoxide binds to the GABA‑A receptor complex, enhancing the inhibitory effect of the neurotransmitter GABA. This results in reduced neuronal excitability, producing anxiolysis, muscle relaxation and sedation, which together help lessen the perception of gastrointestinal pain and associated stress.

The dosage of Librax is individualized and must be determined by a qualified prescriber based on the patient’s condition, age, renal and hepatic function, and response to therapy. Patients should follow the exact instructions provided on the prescription label.

Safety data for Librax during pregnancy and lactation are limited. The potential risks to the fetus or infant are not well defined, so healthcare professionals should weigh the benefits against possible harms and consider alternative therapies when appropriate.

To request Librax, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternatives are single‑component antispasmodics such as dicyclomine or hyoscine. Unlike those agents, Librax combines a benzodiazepine with an anticholinergic, offering both central anxiolytic effects and peripheral smooth‑muscle relaxation, which can be advantageous for patients with significant anxiety‑related GI symptoms.

Librax tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged.

Librax is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals to minimize gastrointestinal irritation.

Serious adverse reactions include severe respiratory depression, marked hypotension, paradoxical agitation, and life‑threatening allergic responses such as anaphylaxis. Patients should seek immediate medical attention if they experience difficulty breathing, extreme drowsiness, fainting, or signs of a severe allergic reaction.

Librax is contraindicated in patients with known hypersensitivity to chlordiazepoxide, clidinium bromide, or any component of the formulation. It should also be avoided in individuals with acute narrow‑angle glaucoma, severe hepatic impairment, or those who are dependent on benzodiazepines without proper medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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