Product image of Licain (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Licain

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Licain (Lidocaine Hydrochloride Monohydrate)

Lidocaine, the active ingredient in Licain, is a local anesthetic presented as a sterile injectable solution for infiltration, intradermal, or intravenous use. It provides rapid, reversible loss of sensation in targeted tissues for minor surgical, dental, and diagnostic procedures. It is commonly used in outpatient settings and is recognized for its rapid onset and short duration of action.

GNH India supplies Licain as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable global distribution.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Licain (lidocaine) is employed to achieve local anesthesia in various minor procedures.

  • Minor surgical procedures: provides targeted numbness to facilitate pain‑free incision and manipulation.
  • Dental procedures: numbs oral tissues to allow painless extractions, restorations, and periodontal work.
  • Diagnostic endoscopic procedures: reduces discomfort during scope insertion and tissue sampling.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel and preventing the rapid influx of sodium ions required for depolarization. By inhibiting the initiation and propagation of action potentials, it halts nerve impulse transmission in the treated area, resulting in reversible loss of sensation. The effect is concentration‑dependent and reversible, with recovery occurring as the drug diffuses away from the nerve fibers.

Side Effects

Lidocaine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Burning or stinging at the injection site
  • Tingling or mild numbness beyond the target area
  • Transient dizziness

Serious or Rare Side Effects

  • Central nervous system toxicity such as seizures
  • Cardiac arrhythmias or hypotension
  • Allergic reactions including rash or anaphylaxis

Precautions & Warnings

When using Licain, several precautions should be observed to minimize risk.

  • Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics.
  • Cardiovascular status: avoid or use with caution in patients with severe heart block or conduction abnormalities.
  • Maximum dose: do not exceed the recommended total dose for the specific route and patient weight.
  • Concomitant CNS depressants: monitor for additive central nervous system effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Lidocaine can interact with other medicines, influencing its plasma concentration or cardiac effects.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase lidocaine levels and risk of toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): can raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers or calcium‑channel blockers: may enhance lidocaine’s cardiac depressant effects.
  • Other local anesthetics: additive toxicity when combined.
  • Diuretics (e.g., furosemide): may alter plasma protein binding and increase free lidocaine.

Frequently Asked Questions

Licain contains lidocaine, which is used to provide local anesthesia for minor surgical, dental, and diagnostic procedures. By numbing a specific area, it allows clinicians to perform interventions without causing pain to the patient.

Lidocaine blocks voltage‑gated sodium channels on nerve membranes, preventing the rapid influx of sodium ions needed for depolarization. This stops the initiation and conduction of nerve impulses, producing a reversible loss of sensation in the treated region.

The dose of Licain is determined by the prescribing clinician based on the procedure, route of administration, patient weight, and clinical guidelines. No fixed dosing information is provided here; the prescriber sets the appropriate regimen.

Safety data for lidocaine in pregnancy and lactation are limited. Use only if the potential benefit justifies any potential risk to the fetus or infant, and always consult a healthcare professional before administration.

Enquiries for Licain can be submitted on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lidocaine, the active ingredient in Licain, has a rapid onset (1–2 minutes) and a moderate duration (30–120 minutes) compared with agents such as bupivacaine, which lasts longer but has a slower onset. Choice depends on the clinical need for speed versus duration.

Licain should be stored at 2‑8 °C, kept refrigerated, protected from light, and never frozen. It must be handled in a clean environment, and any vial or ampoule should be inspected for particulate matter before use.

Licain is administered by infiltration, intradermal injection, or intravenous infusion, depending on the intended procedure. The healthcare professional selects the appropriate route, prepares the sterile solution, and injects it directly into or around the target tissue.

Serious risks include central nervous system toxicity (e.g., seizures), cardiovascular effects such as arrhythmias or hypotension, and severe allergic reactions that can lead to anaphylaxis. Immediate medical attention is required if any of these symptoms occur.

Licain should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, severe heart block, uncontrolled epilepsy, or those taking medications that significantly raise lidocaine plasma levels without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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