Product image of Lidbree (Lidocaine) supplied by GNH India

Lidbree

Active Ingredient:
Lidocaine
Origin:
EU

Lidbree (Lidocaine)

Lidocaine, the active ingredient in Lidbree, is a local anesthetic presented as a sterile intrauterine solution for intrauterine use. It provides targeted analgesia during uterine procedures, helping to reduce pain for women undergoing interventions such as hysteroscopy, intrauterine device placement, or uterine curettage.

GNH India supplies Lidbree as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑ready documentation for global distribution. It offers reliable cold‑chain logistics where required to maintain product integrity.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Lidbree, containing lidocaine, is employed for analgesia in intrauterine procedures and related gynecologic interventions.

  • Hysteroscopic procedures: provides local anesthesia of the uterine cavity to reduce procedural pain.
  • Intrauterine device (IUD) insertion: minimizes discomfort during placement of contraceptive devices.
  • Uterine curettage: facilitates analgesia during scraping of the uterine lining.

How It Works

  • Lidocaine exerts its effect by reversibly binding to the intracellular portion of voltage‑gated sodium channels on neuronal membranes. This blockade prevents the rapid influx of sodium ions during depolarization, thereby inhibiting the generation and propagation of nerve impulses. In the uterine tissue, the localized inhibition of sensory nerve conduction results in loss of pain perception without affecting uterine contractility at therapeutic concentrations.

Side Effects

Lidbree may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Local burning sensation at the application site
  • Mild uterine cramping
  • Nausea
  • Dizziness or headache

Serious or Rare Side Effects

  • Allergic reactions including rash, angioedema, or anaphylaxis
  • Methemoglobinemia leading to cyanosis
  • Cardiac arrhythmias such as ventricular tachycardia
  • Central nervous system toxicity presenting as seizures or loss of consciousness

Precautions & Warnings

When using Lidbree, clinicians should observe several precautionary measures to ensure patient safety.

  • Assess allergy: verify patient has no known hypersensitivity to lidocaine or amide‑type local anesthetics.
  • Monitor cardiac status: observe for signs of arrhythmia or hypotension during and after administration.
  • Use lowest effective dose: limit exposure to the minimum amount required for analgesia.
  • Avoid in severe hepatic impairment: reduced metabolism may increase systemic toxicity.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lidbree can interact with other medicines, influencing its safety profile.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase systemic lidocaine toxicity.
  • Beta‑blockers (e.g., propranolol): can potentiate cardiotoxic effects of lidocaine.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): raise plasma lidocaine concentrations.

Moderate Interactions (Monitor Closely)

  • Class III antiarrhythmics (e.g., amiodarone, sotalol): may modestly elevate lidocaine levels.
  • Concurrent use of other local anesthetics: cumulative toxicity risk.
  • Epinephrine administered nearby: can alter lidocaine absorption and prolong action.

Frequently Asked Questions

Lidbree is a sterile intrauterine formulation of lidocaine that provides local anesthesia for gynecologic procedures. It is commonly employed to reduce pain during hysteroscopic examinations, intrauterine device (IUD) placement, and uterine curettage, offering targeted analgesia without systemic sedation.

Lidocaine works by reversibly blocking voltage‑gated sodium channels on nerve membranes. This inhibition stops the rapid influx of sodium ions needed for depolarisation, preventing the generation and spread of pain signals. In the uterus, the effect is confined to the site of application, producing localized loss of sensation.

The appropriate dose of Lidbree is determined by the prescribing clinician based on the specific procedure, patient characteristics, and institutional protocols. Dosage recommendations are not publicly disclosed and should be obtained from the treating physician or the product’s prescribing information.

Safety data for intrauterine lidocaine during pregnancy and lactation are limited. Use is generally reserved for situations where the benefit outweighs potential risk, and it should be administered under close medical supervision. Breastfeeding mothers should consult their healthcare provider before use.

To order Lidbree, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including cold‑chain where applicable) and assists with import documentation.

Lidbree contains lidocaine, an amide‑type local anesthetic with a rapid onset and moderate duration. Compared with bupivacaine, another intrauterine anesthetic, lidocaine acts faster but has a shorter duration of analgesia. Choice between agents depends on procedural length, desired onset time, and patient‑specific safety considerations.

Lidbree should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperature fluctuations. Follow any additional handling instructions provided by the manufacturer to maintain sterility and potency.

Lidbree is administered via intrauterine injection. After aseptic preparation, the solution is introduced into the uterine cavity using a suitable catheter or syringe, allowing the anesthetic to diffuse locally. Administration is performed by trained healthcare professionals following standard procedural protocols.

Serious risks include systemic toxicity such as cardiac arrhythmias, central nervous system effects like seizures, severe allergic reactions (anaphylaxis), and rare cases of methemoglobinemia. Prompt recognition of symptoms and immediate medical intervention are essential to mitigate these potentially life‑threatening events.

Lidbree should be avoided in patients with known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe hepatic impairment, and individuals with pre‑existing cardiac conduction abnormalities or uncontrolled arrhythmias. Contraindications must be confirmed by the prescribing clinician before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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