Product image of Lidbree (Lidocaine) supplied by GNH India

Lidbree

Active Ingredient:
Lidocaine
Origin:
EU

Lidbree (Lidocaine)

Lidocaine, the active ingredient in Lidbree, is a local anesthetic presented as a sterile solution for intrauterine use. It provides temporary loss of sensation during intrauterine procedures and is administered by qualified health professionals. Lidbree is indicated for procedures that require localized uterine anesthesia.

GNH India supplies Lidbree as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Lidocaine is a local anesthetic used in intrauterine procedures to achieve temporary loss of sensation.

  • Intrauterine procedures: provides local anesthesia during hysteroscopic surgery, endometrial ablation, and intrauterine device placement.
  • Diagnostic hysteroscopy: facilitates patient comfort while allowing detailed uterine evaluation.
  • Therapeutic uterine interventions: enables pain control for operative procedures such as polypectomy or myomectomy.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. By stabilizing the neuronal membrane, it inhibits nerve impulse transmission in the targeted uterine tissue, resulting in localized loss of sensation without affecting systemic consciousness.

Side Effects

Lidocaine administered intrauterinely may cause a range of adverse reactions.

Common Side Effects

  • Uterine cramping: mild to moderate discomfort during or after administration.
  • Vaginal bleeding: transient spotting or light bleeding.
  • Nausea: occasional mild nausea.
  • Headache: brief headache episodes.
  • Dizziness: transient light‑headedness.
  • Local irritation: mild irritation at the application site.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or anaphylaxis.
  • Severe hypotension: sudden drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Methemoglobinemia: reduced oxygen‑carrying capacity of blood.
  • Central nervous system toxicity: seizures or altered mental status.
  • Persistent uterine pain: prolonged severe pain requiring medical attention.

Precautions & Warnings

Lidbree should be used with careful consideration of patient‑specific factors and handling requirements.

  • Pregnancy: safety not established; avoid unless essential.
  • Breastfeeding: unknown safety; weigh potential risks.
  • Allergy: contraindicated in patients with known lidocaine hypersensitivity.
  • Cardiovascular disease: use with caution; monitor heart rate and blood pressure.
  • Storage: Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Lidbree may interact with other medications that affect cardiac or metabolic pathways.

Major Interactions (Avoid)

  • Class I antiarrhythmic drugs (e.g., quinidine, procainamide): additive cardiotoxicity.
  • Beta‑blockers: may enhance bradycardia.
  • CYP3A4 inhibitors (e.g., ketoconazole): increase lidocaine plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers (e.g., rifampin): may reduce lidocaine efficacy.
  • Concurrent local anesthetics: risk of cumulative toxicity.
  • General anesthetics: potential potentiation of central nervous system depression.

Frequently Asked Questions

Lidbree is a sterile intrauterine solution containing lidocaine, used to provide local anesthesia during intrauterine procedures such as hysteroscopy, endometrial ablation, and intrauterine device placement. It helps reduce pain and discomfort for the patient while allowing the clinician to perform the procedure safely.

Lidocaine works by blocking voltage‑gated sodium channels on nerve cells within the uterine tissue. This inhibition prevents the generation and conduction of nerve impulses, resulting in a localized loss of sensation without affecting the patient's overall consciousness.

The specific dose of Lidbree is determined by the prescribing clinician based on the type of intrauterine procedure, patient characteristics, and clinical guidelines. Healthcare professionals calculate the appropriate volume and concentration required for each individual case.

Safety of Lidbree in pregnancy and breastfeeding has not been established. It should only be used when clearly needed and after a risk‑benefit assessment by the treating physician. Women who are pregnant or nursing should discuss potential risks with their healthcare provider.

To order Lidbree, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lidbree’s active ingredient, lidocaine, is a widely used local anesthetic with a rapid onset and moderate duration of action. Compared with other intrauterine anesthetics, lidocaine offers a well‑characterized safety profile, predictable pharmacokinetics, and extensive clinical experience, making it a common choice for uterine procedures.

Lidbree should be stored below 25 °C, protected from light and moisture, and kept in its original packaging. Avoid freezing the product. Before use, inspect the solution for any discoloration or particulate matter and follow aseptic techniques during administration.

Lidbree is administered intrauterinely by a qualified healthcare professional. The solution is injected directly into the uterine cavity using a sterile catheter or applicator, following standard procedural protocols to ensure accurate placement and optimal anesthetic effect.

Serious risks, though rare, include allergic reactions such as anaphylaxis, severe hypotension, cardiac arrhythmias, methemoglobinemia, and central nervous system toxicity leading to seizures. Immediate medical attention is required if any of these symptoms occur.

Lidbree should not be used in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics. Caution is also advised for individuals with significant cardiac conduction disorders, severe liver disease, or those taking medications that may cause additive cardiotoxic effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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