Product image of Lidbree (Lidocaine) supplied by GNH India

Lidbree

Active Ingredient:
Lidocaine
Origin:
EU

Lidbree (Lidocaine)

Lidocaine, the active ingredient in Lidbree, is an amide‑type local anesthetic presented as a sterile solution for intrauterine use. Approved in the European Union, it provides targeted numbing of uterine tissue to facilitate gynecologic procedures and reduce procedural discomfort.

GNH India supplies Lidbree as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global logistics for regulated medicines. Customers benefit from consistent batch release and regulatory support.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Lidbree, a lidocaine formulation, is used for intrauterine anesthesia in several gynecologic procedures.

  • Hysteroscopic procedures: provides local uterine anesthesia to improve patient comfort during diagnostic and operative hysteroscopy.
  • IUD insertion: reduces pain associated with intrauterine device placement.
  • Uterine curettage or dilation and curettage: facilitates analgesia during tissue removal.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the rapid influx of sodium ions required for depolarization. By stabilizing the neuronal membrane, it inhibits initiation and propagation of nerve impulses in the treated area, resulting in reversible loss of sensation without affecting surrounding tissues. The effect is concentration‑dependent and reversible, allowing rapid onset of anesthesia and recovery as the drug is metabolized by hepatic enzymes.

Side Effects

Lidocaine administered intrauterinely may be associated with the following adverse reactions.

Common Side Effects

  • Uterine cramping
  • Vaginal bleeding or spotting
  • Nausea or vomiting
  • Dizziness or headache

Serious or Rare Side Effects

  • Allergic reaction (rash, itching, anaphylaxis)
  • Cardiovascular toxicity (arrhythmias, hypotension)
  • Central nervous system toxicity (seizures, altered consciousness)
  • Methemoglobinemia (blue‑tinged skin, cyanosis)

Precautions & Warnings

When using Lidbree, consider the following precautions to ensure safe administration.

  • Allergy assessment: verify no known hypersensitivity to lidocaine or amide‑type anesthetics.
  • Cardiac monitoring: observe patients with pre‑existing conduction disorders or arrhythmias.
  • Dose limitation: employ the lowest effective volume to achieve anesthesia.
  • Hepatic function: use caution in severe liver impairment due to reduced metabolism.
  • Pregnancy and lactation: limit use to situations where benefits outweigh potential risks.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lidbree may interact with other medicines; awareness of key interactions helps prevent toxicity.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): increase systemic lidocaine toxicity.
  • Beta‑blockers (e.g., propranolol): may enhance lidocaine’s cardiac depressant effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): raise plasma lidocaine concentrations.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers (e.g., rifampicin, carbamazepine): may reduce lidocaine levels.
  • Concurrent use of other local anesthetics: additive neuro‑ and cardiotoxicity risk.
  • General anesthetics (e.g., propofol, volatile agents): may potentiate CNS depression.

Frequently Asked Questions

Lidbree is a lidocaine‑based sterile solution intended for intrauterine anesthesia. It is employed to numb the uterus during gynecologic procedures such as hysteroscopy, intrauterine device (IUD) placement, and uterine curettage, helping to reduce procedural pain and improve patient comfort.

Lidocaine blocks voltage‑gated sodium channels on nerve membranes, preventing the rapid influx of sodium that initiates an action potential. This stabilises the neuronal membrane, halting the transmission of pain signals from the treated area and producing a reversible loss of sensation.

The specific dose of Lidbree is determined by the prescribing clinician based on the procedure, patient characteristics, and clinical guidelines. Healthcare professionals calculate the appropriate volume and concentration to achieve effective uterine anesthesia while minimizing systemic exposure.

Safety data for intrauterine lidocaine during pregnancy and lactation are limited. It should only be used when the expected benefit justifies any potential risk to the mother or fetus. Clinicians should evaluate each case individually and follow local regulatory recommendations.

To request Lidbree, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Lidbree contains lidocaine, an amide‑type local anesthetic with a rapid onset and moderate duration of action. Compared with ester‑type agents, lidocaine generally offers a lower risk of allergic reactions and predictable metabolism. Choice of agent depends on clinician preference, procedural requirements, and patient-specific factors.

Lidbree should be stored at room temperature, below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze the solution, and inspect the vial for any particulate matter before use.

Lidbree is administered by a qualified healthcare professional directly into the uterine cavity using a sterile applicator or catheter. The volume injected is calculated to achieve adequate local anesthesia while avoiding systemic absorption. Standard aseptic technique and patient monitoring are recommended throughout the procedure.

Serious risks include allergic reactions such as anaphylaxis, cardiovascular toxicity (e.g., arrhythmias, severe hypotension), central nervous system toxicity (e.g., seizures, altered consciousness), and rare cases of methemoglobinemia. Prompt recognition and supportive management are essential if any of these events occur.

Lidbree should be avoided in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe hepatic impairment, and individuals with significant cardiac conduction disorders unless the benefits clearly outweigh the risks. Consultation with a specialist is advised for high‑risk patients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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