Product image of Lidene (Doxylamine Hydrogen Succinate) supplied by GNH India

Lidene

Active Ingredient:
Doxylamine Hydrogen Succinate
Origin:
EU

Lidene (Doxylamine Hydrogen Succinate)

Doxylamine Hydrogen Succinate, the active ingredient in Lidene, is a first‑generation H1 antihistamine presented as an oral dosage form for oral use. It is used as a short‑term sleep aid and to relieve symptoms of allergic rhinitis and the common cold.

GNH India supplies Lidene as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Cooperation Pharmaceutique Francaise

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Indications & Clinical Uses

Lidene, a first‑generation H1 antihistamine, acts on allergic and sedative pathways to provide symptom relief.

  • Insomnia (short‑term): Helps initiate and maintain sleep in adults needing temporary relief.
  • Allergic rhinitis: Reduces nasal congestion, sneezing and itching associated with seasonal allergies.
  • Common cold symptoms: Alleviates runny nose and sneezing during acute viral upper respiratory infections.

How It Works

  • Doxylamine Hydrogen Succinate competitively blocks peripheral H1 histamine receptors, preventing histamine‑mediated allergic responses, while its central anticholinergic activity produces sedation by inhibiting central nervous system histaminergic transmission.

Side Effects

Lidene may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Blurred vision: temporary difficulty focusing.
  • Constipation: slowed gastrointestinal motility.
  • Urinary retention: difficulty emptying the bladder.
  • Dizziness: sensation of light‑headedness or imbalance.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with rash, swelling and breathing difficulty.
  • Cardiac arrhythmia: irregular heart rhythm requiring medical attention.
  • Seizures: rare occurrence of convulsive episodes.
  • Hallucinations or severe confusion: altered mental status, especially in the elderly.

Precautions & Warnings

Before using Lidene, consider the following safety measures.

  • Assess need for sedation: evaluate the patient's sleep disorder and alternative therapies.
  • Avoid use with alcohol: concurrent consumption can intensify CNS depression.
  • Caution in elderly: higher susceptibility to anticholinergic effects and falls.
  • Review concomitant medications: watch for additive sedation with other CNS depressants.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lidene can interact with other substances; monitor patients accordingly.

Major Interactions (Avoid)

  • Alcohol and other CNS depressants: may cause profound sedation and respiratory depression.
  • Opioid analgesics: combined use can increase risk of respiratory depression and excessive drowsiness.
  • Other first‑generation antihistamines: additive anticholinergic and sedative effects.

Moderate Interactions (Monitor Closely)

  • Cimetidine: can raise doxylamine plasma concentrations, requiring observation for enhanced effects.
  • Theophylline: may increase seizure risk when combined with doxylamine.

Frequently Asked Questions

Lidene contains doxylamine hydrogen succinate and is indicated for short‑term relief of insomnia, for alleviating symptoms of allergic rhinitis such as sneezing and nasal congestion, and for reducing runny nose and sneezing associated with the common cold.

Doxylamine hydrogen succinate blocks peripheral H1 histamine receptors, preventing the typical allergic response, while its central anticholinergic activity suppresses histaminergic neurotransmission in the brain, producing a sedative effect that helps initiate sleep.

The appropriate dose of Lidene is determined by the prescribing healthcare professional based on the patient’s age, condition and response to therapy. Dosage recommendations follow local prescribing information and should not be altered without medical guidance.

Safety data for doxylamine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lidene.

To order Lidene, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Lidene (doxylamine) and diphenhydramine are first‑generation antihistamines with sedative properties. Doxylamine generally has a longer half‑life, providing more sustained sleep support, while diphenhydramine may wear off earlier. Choice depends on individual response, duration of action needed and tolerability of side effects.

Lidene should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain potency and stability throughout its shelf life.

Lidene is taken orally, usually with a full glass of water. It is typically taken shortly before bedtime for insomnia or as directed for allergy or cold symptoms. Follow the prescribing clinician’s instructions regarding timing and whether it should be taken with food.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, cardiac arrhythmias, seizures, and profound confusion or hallucinations. If any of these occur, seek immediate medical attention.

Lidene should be avoided in individuals with known hypersensitivity to doxylamine or other first‑generation antihistamines, in patients with severe hepatic impairment, and in those taking monoamine oxidase inhibitors. Caution is also advised for the elderly and for anyone with uncontrolled narrow‑angle glaucoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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