Product image of Lidocain-Adrenalin (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocain-Adrenalin

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocain-Adrenalin (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride and epinephrine, the active ingredient in Lidocain-Adrenalin, is a local anesthetic with vasoconstrictor presented as an unspecified strength and form for epidural use. It provides rapid onset anesthesia and prolonged analgesia for surgical procedures and labor in adult patients.

GNH India supplies Lidocain-Adrenalin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Lidocain-Adrenalin is used in the epidural space to achieve local anesthesia and analgesia for various clinical situations.

  • Surgical procedures: provides reliable epidural anesthesia for operations requiring muscle relaxation and pain control.
  • Labor pain management: delivers effective analgesia during childbirth while maintaining maternal hemodynamic stability.
  • Post‑operative pain control: extends analgesic effect after surgery to reduce the need for systemic opioids.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarization and impulse transmission. Epinephrine activates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that reduces local blood flow, limits systemic absorption of lidocaine, and prolongs its anesthetic effect within the epidural space.

Side Effects

Adverse reactions may occur following epidural administration of Lidocain-Adrenalin.

Common Side Effects

  • Hypotension: transient drop in blood pressure due to vasodilation.
  • Tachycardia: increased heart rate from systemic epinephrine.
  • Nausea or vomiting: gastrointestinal upset.
  • Dizziness or light‑headedness.
  • Local site irritation or itching at the injection site.

Serious or Rare Side Effects

  • Severe hypertension or arrhythmias.
  • Cardiovascular collapse or cardiac arrest.
  • Seizures due to high plasma lidocaine levels.
  • Anaphylactic or severe allergic reactions.
  • Methemoglobinemia in susceptible individuals.

Precautions & Warnings

When using Lidocain-Adrenalin, clinicians should observe several safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart rate before administration.
  • Hypertension caution: avoid high‑dose epinephrine in patients with uncontrolled hypertension.
  • Hypersensitivity screening: do not use in individuals with known allergy to lidocaine or epinephrine.
  • Fetal monitoring: observe fetal heart rate when administered during labor.
  • Beta‑blocker interaction: adjust monitoring if the patient is on non‑selective beta‑blockers.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lidocain-Adrenalin may interact with other medications that affect cardiovascular or nervous system function.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Non‑selective beta‑blockers: may potentiate bradycardia and hypotension.
  • Tricyclic antidepressants: increase risk of arrhythmias.
  • Other vasoconstrictors (e.g., phenylephrine): may cause severe hypertension.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative toxicity risk.
  • Sympathomimetic agents: additive cardiovascular effects.
  • Diuretics: may alter plasma lidocaine concentrations.
  • Anticonvulsants: monitor for seizure threshold changes.

Frequently Asked Questions

Lidocain-Adrenalin is an epidural formulation that combines lidocaine and epinephrine to provide rapid, localized anesthesia and prolonged analgesia for surgical procedures, labor pain management, and postoperative pain control in adult patients.

Lidocaine blocks sodium channels on nerve fibers, preventing impulse transmission, while epinephrine stimulates alpha‑adrenergic receptors causing vasoconstriction. This reduces local blood flow, limits systemic absorption of lidocaine, and extends the duration of the anesthetic effect.

The specific dose and concentration are determined by the prescribing clinician based on the procedure, patient characteristics, and desired depth of anesthesia. Dosing should follow local practice guidelines and the product’s prescribing information.

Safety data for epidural use of lidocaine‑epinephrine combinations in pregnancy are limited. The drug should only be used when clearly needed and after careful risk‑benefit assessment by the obstetric team. Breastfeeding considerations follow standard guidelines for local anesthetics.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with plain lidocaine, the addition of epinephrine offers vasoconstriction that prolongs anesthetic duration and reduces systemic exposure. Relative to bupivacaine, lidocaine provides a faster onset but a shorter duration, making it suitable for shorter procedures or when rapid recovery is desired.

Store the product at room temperature, preferably below 25 °C, in its original packaging. Protect it from moisture, direct sunlight, and extreme temperatures to maintain potency and sterility.

The medication is administered by a qualified healthcare professional via epidural injection. Proper aseptic technique, correct needle placement, and incremental dosing are essential to achieve effective anesthesia while minimizing complications.

Serious risks include severe hypertension, cardiac arrhythmias, cardiovascular collapse, seizures from high plasma lidocaine levels, and rare anaphylactic reactions. Immediate monitoring and emergency preparedness are required during administration.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, certain cardiac conduction disorders, or those taking non‑selective beta‑blockers without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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