Product image of Lidocain-Adrenalin (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocain-Adrenalin

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocain-Adrenalin (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride and epinephrine, the active ingredient in Lidocain-Adrenalin, is a local anesthetic with vasoconstrictor presented as a solution for intramuscular and subcutaneous use. It provides local anesthesia for minor surgical or dermatologic procedures and pain control during injections.

GNH India supplies Lidocain-Adrenalin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Lidocain-Adrenalin, a combination local anesthetic with vasoconstrictor, is used in procedures requiring temporary loss of sensation.

  • Minor surgical procedures: provides localized anesthesia to facilitate surgery.
  • Dermatologic procedures: enables painless excision or biopsy of skin lesions.
  • Subcutaneous or intramuscular injections: reduces pain and prolongs anesthetic effect during injection.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing propagation of nerve impulses. Epinephrine activates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that limits systemic absorption of lidocaine, prolongs its local effect, and reduces bleeding at the injection site.

Side Effects

Lidocain-Adrenalin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tingling or numbness at injection site: transient sensory changes.
  • Mild swelling or redness: local irritation.
  • Elevated heart rate: mild tachycardia.
  • Headache: occasional.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis, hives, facial swelling.
  • Cardiac arrhythmia: irregular heartbeat, especially with high epinephrine exposure.
  • Methemoglobinemia: reduced oxygen‑carrying capacity of blood.
  • Seizures: central nervous system excitation.

Precautions & Warnings

Before administering Lidocain-Adrenalin, clinicians should consider several safety measures.

  • Patient history: assess for allergy to lidocaine or epinephrine before use.
  • Cardiovascular disease: avoid or use with caution in patients with hypertension, arrhythmias, or coronary artery disease.
  • Thyroid disorders: monitor in patients with hyperthyroidism due to epinephrine effects.
  • Use in children: adjust dose carefully and monitor for systemic toxicity.
  • Drug interactions: review concomitant medications that may potentiate epinephrine effects.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidocain-Adrenalin can interact with several drug classes, requiring attention to avoid adverse events.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis with epinephrine.
  • Beta‑blockers: may mask epinephrine‑induced tachycardia and increase blood pressure.
  • Tricyclic antidepressants: can enhance lidocaine toxicity.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may increase risk of cardiac effects.
  • Diuretics: can alter plasma lidocaine levels.
  • Sympathomimetic drugs: additive vasoconstrictive effects.

Frequently Asked Questions

Lidocain-Adrenalin is a combination of lidocaine and epinephrine used to provide local anesthesia for minor surgical or dermatologic procedures and to reduce pain during subcutaneous or intramuscular injections. The vasoconstrictor effect of epinephrine prolongs the anesthetic action and limits bleeding at the injection site.

Lidocaine blocks voltage‑gated sodium channels on nerve fibers, stopping the transmission of pain signals. Epinephrine stimulates alpha‑adrenergic receptors on blood vessels, causing vasoconstriction. This reduces systemic absorption of lidocaine, extends its local effect, and minimizes bleeding during the procedure.

The appropriate dose of Lidocain-Adrenalin is determined by the prescribing clinician based on the specific procedure, patient weight, age, and clinical condition. Healthcare professionals calculate the volume and concentration needed to achieve effective anesthesia while staying within safety limits.

Safety data for Lidocain-Adrenalin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it should be administered under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Plain lidocaine provides rapid local anesthesia but has a shorter duration and may cause more bleeding. Adding epinephrine creates a vasoconstrictive effect that prolongs anesthesia, reduces systemic absorption, and minimizes intra‑procedural bleeding, making the combination preferable for longer or more vascular procedures.

Lidocain-Adrenalin should be stored at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from direct light and moisture, and avoid freezing. Inspect the solution for particulate matter or discoloration before use.

The product is administered by a qualified healthcare professional via subcutaneous or intramuscular injection. The injection site is selected based on the intended procedure, and the solution is delivered using aseptic technique to ensure effective local anesthesia.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias or hypertension due to epinephrine, methemoglobinemia, and central nervous system toxicity such as seizures. Prompt recognition and treatment of these events are essential.

Patients with a known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid the product. It is also contraindicated in individuals with severe cardiovascular disease, uncontrolled hyperthyroidism, or those taking monoamine oxidase inhibitors without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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