Product image of Lidocain/Adrenalin Orion (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocain/Adrenalin Orion

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocain/Adrenalin Orion (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride and epinephrine, the active ingredients in Lidocain/Adrenalin Orion, are a local anesthetic combination presented as a solution for perineural use. It provides regional anesthesia for peripheral nerve blocks and surgical procedures requiring localized pain control.

GNH India supplies Lidocain/Adrenalin Orion as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Lidocain/Adrenalin Orion is used in the local anesthetic pathway to achieve targeted nerve blockade and surgical analgesia.

  • Peripheral nerve block: produces prolonged regional anesthesia for limb surgeries.
  • Dental procedures: extends the duration of local anesthesia for oral surgeries.
  • Minor surgical procedures: facilitates pain‑free incision and tissue manipulation.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarization and impulse transmission. Epinephrine stimulates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that reduces systemic absorption of lidocaine, thereby prolonging its anesthetic effect and limiting bleeding at the injection site.

Side Effects

Lidocain/Adrenalin Orion may cause a range of adverse reactions.

Common Side Effects

  • Tingling or numbness at the injection site.
  • Mild headache.
  • Transient increase in heart rate.
  • Localized swelling or bruising.
  • Temporary dizziness.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Cardiac arrhythmias or hypertension.
  • Methemoglobinemia.
  • Central nervous system toxicity (seizures, loss of consciousness).
  • Persistent numbness beyond expected duration.

Precautions & Warnings

Before using Lidocain/Adrenalin Orion, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to lidocaine, epinephrine, or related compounds.
  • Cardiovascular status: avoid in patients with uncontrolled hypertension or significant arrhythmias.
  • Dosage limits: adhere strictly to prescribed maximum doses to prevent systemic toxicity.
  • Concomitant vasoconstrictors: use caution when combined with other agents that affect blood pressure.
  • Pediatric use: adjust dosing carefully and monitor closely.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidocain/Adrenalin Orion can interact with several medications.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may potentiate hypertensive crisis.
  • Beta‑blockers: can mask epinephrine‑induced tachycardia and increase risk of severe hypertension.
  • Class I antiarrhythmics (e.g., quinidine): increase risk of cardiac toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may enhance bleeding risk.
  • Tricyclic antidepressants: may lower seizure threshold.
  • Diuretics: may affect plasma electrolyte balance, influencing lidocaine toxicity.

Frequently Asked Questions

Lidocain/Adrenalin Orion is a combination of lidocaine and epinephrine used to provide regional anesthesia for peripheral nerve blocks, dental procedures, and minor surgical interventions. The epinephrine component prolongs the anesthetic effect by constricting blood vessels at the injection site.

Lidocaine blocks voltage‑gated sodium channels on nerve cells, preventing the initiation and propagation of electrical impulses. This interruption stops pain signals from reaching the brain, resulting in a loss of sensation in the targeted area.

The specific dose of Lidocain/Adrenalin Orion is determined by the prescribing clinician based on the procedure, patient weight, and clinical judgment. Only a qualified healthcare professional should calculate and administer the appropriate amount.

Safety data for Lidocain/Adrenalin Orion in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with lidocaine alone, the addition of epinephrine in Lidocain/Adrenalin Orion reduces systemic absorption, prolongs the duration of anesthesia, and minimizes intra‑operative bleeding. This can be advantageous for longer procedures or when a more sustained block is desired.

Store the product at room temperature, preferably below 25 °C, in its original packaging. Protect it from direct light, moisture, and extreme temperatures to maintain stability and potency.

The medication is administered perineurally by a qualified healthcare professional using aseptic technique. It is injected directly around the target nerve or nerve plexus to achieve localized anesthesia.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias or hypertension due to epinephrine, central nervous system toxicity such as seizures, and rare cases of methemoglobinemia. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, certain cardiac arrhythmias, or those taking MAO inhibitors without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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