Product image of Lidocain-Egis (Lidocaine) supplied by GNH India

Lidocain-Egis

Active Ingredient:
Lidocaine
Origin:
EU

Lidocain-Egis (Lidocaine)

Lidocaine, the active ingredient in Lidocain‑Egis, is a local anesthetic presented as an oromucosal preparation for topical mucosal use. It provides temporary numbing of oral tissues to relieve pain associated with mucosal irritation, dental procedures, and related conditions.

GNH India supplies Lidocain‑Egis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. It is manufactured under EU GMP guidelines and exported to multiple regions.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

  • Lidocaine acts locally on oral mucosal tissues to provide analgesia for several common conditions.
  • Oral mucositis: reduces pain from chemotherapy‑induced mucosal lesions, allowing better nutrition and comfort.
  • Dental procedures: provides temporary numbness of the oral mucosa to facilitate minor surgical or diagnostic work.
  • Sore throat relief: alleviates discomfort associated with inflammatory throat conditions by numbing the affected area.

How It Works

  • Lidocaine exerts its effect by reversibly binding to the intracellular portion of voltage‑gated sodium channels on neuronal membranes. This blockade prevents the rapid influx of sodium ions during depolarization, thereby inhibiting the generation and propagation of nerve impulses. The result is a localized loss of sensation without affecting surrounding tissues. The reversible nature allows normal sensation to return as the drug is metabolized, typically within minutes after application.

Side Effects

Lidocaine may cause local and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

  • Taste alteration: temporary metallic or bitter taste in the mouth.
  • Burning sensation: mild burning or stinging at the application site.
  • Numbness: localized loss of sensation lasting a short period.
  • Dizziness: transient light‑headedness, especially with higher exposure.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis requiring immediate medical attention.
  • Methemoglobinemia: reduced oxygen‑carrying capacity of blood, presenting with cyanosis.
  • Cardiac toxicity: arrhythmias or conduction disturbances, particularly with excessive systemic absorption.

Precautions & Warnings

When using Lidocain‑Egis, consider the following precautions to minimize risk.

  • Assess allergy: confirm no known hypersensitivity to lidocaine or related amide anesthetics.
  • Limit area: apply only to the intended mucosal surface and avoid excessive quantity.
  • Monitor systemic exposure: watch for signs of toxicity if large areas are treated or if used repeatedly.
  • Use with caution in cardiac patients: consider underlying conduction disorders before extensive use.
  • Avoid use with other local anesthetics: concurrent application may increase toxicity.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Lidocain‑Egis can interact with several medicines; awareness of these interactions helps prevent adverse effects.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase systemic lidocaine levels and risk of cardiac toxicity.
  • Other local anesthetics: additive nerve and cardiac toxicity when used together.
  • CYP3A4 inhibitors (e.g., erythromycin, ketoconazole): can raise plasma concentrations of lidocaine.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may enhance bradycardic effects when systemic absorption occurs.
  • Diuretics (e.g., furosemide): can alter plasma protein binding, affecting lidocaine activity.
  • Alcohol: concurrent use may increase central nervous system depression.

Frequently Asked Questions

Lidocain‑Egis is a lidocaine‑based oromucosal product used to provide temporary local anesthesia of the oral mucosa. It is commonly employed to relieve pain from oral mucositis, to numb tissue during dental procedures, and to ease discomfort associated with sore throat or other inflammatory conditions of the mouth and throat.

Lidocaine works by reversibly blocking voltage‑gated sodium channels on nerve cells. This inhibition prevents the rapid influx of sodium ions needed for depolarisation, thereby stopping the generation and propagation of pain signals. The effect is confined to the area of application, producing localized numbness without systemic anaesthesia.

The dose of Lidocain‑Egis is determined by the prescribing healthcare professional based on the specific indication, the size of the mucosal area to be treated, patient age, and overall health status. The prescriber will decide the amount and frequency of application to achieve effective pain relief while minimising the risk of toxicity.

Safety data for Lidocain‑Egis in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider before starting treatment.

To order Lidocain‑Egis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lidocain‑Egis contains lidocaine, an amide‑type local anesthetic with a rapid onset and moderate duration of action. Compared with benzocaine, another topical anesthetic, lidocaine generally provides a deeper level of numbness and a lower risk of methemoglobinemia. However, both agents share similar precautions regarding allergic reactions and systemic toxicity when used excessively.

Lidocain‑Egis should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use. Do not freeze the product, and keep it out of reach of children.

Lidocain‑Egis is applied directly to the oral mucosa using the supplied applicator or a clean fingertip. The recommended amount is spread evenly over the affected area, avoiding ingestion. Administration is performed by a healthcare professional or, when appropriate, by the patient following the prescriber's instructions.

The most serious risks include allergic reactions that can progress to anaphylaxis, methemoglobinemia which reduces the blood’s ability to carry oxygen, and cardiac toxicity such as arrhythmias or conduction disturbances, especially after large‑area or repeated applications that lead to systemic absorption.

Lidocain‑Egis should be avoided in individuals with a known hypersensitivity to lidocaine or other amide‑type local anesthetics. Patients with severe cardiac conduction disorders, uncontrolled heart disease, or a history of methemoglobinemia should also refrain from using the product unless specifically directed by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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