Lidocain-Hcl B. Braun (Lidocaine Hydrochloride Monohydrate)

Lidocaine is a local anesthetic used across several procedural pathways to achieve temporary loss of sensation.

• Epidural analgesia: provides effective pain relief during labor, surgery or postoperative periods.
• Infiltration anesthesia for minor surgical procedures: numbs targeted tissue to allow minor incisions or suturing.
• Intradermal anesthesia for diagnostic testing: enables painless skin testing such as allergy or sensory assessments.
• Subcutaneous anesthesia: facilitates minor procedures like catheter insertions or biopsies.

• Lidocaine reversibly blocks voltage‑gated sodium channels on neuronal membranes, preventing the rapid influx of sodium ions required for depolarisation. This inhibition stops the initiation and propagation of nerve impulses, resulting in a temporary loss of sensation in the administered area without affecting surrounding tissues.

Lidocaine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Burning or stinging at the injection site
• Mild hypotension or dizziness
• Nausea or metallic taste
• Local swelling or erythema
• Headache
• Transient tinnitus

Serious or Rare Side Effects

• Systemic toxicity leading to seizures or cardiac arrhythmias
• Severe allergic reactions including anaphylaxis
• Methemoglobinemia
• Respiratory depression
• Profound hypotension or cardiovascular collapse
• Persistent neurological deficits

Before using Lidocain-Hcl B. Braun, clinicians should consider patient‑specific factors and procedural context.

• Allergy assessment: verify no known hypersensitivity to lidocaine or other amide‑type anesthetics.
• Hepatic function: adjust dosage in patients with significant liver impairment.
• Cardiac monitoring: observe heart rate and rhythm during epidural administration.
• Pediatric use: apply weight‑based dosing and monitor closely.
• Concomitant local anesthetics: avoid simultaneous use of multiple amide anesthetics.
• Storage: Store below 25°C: keep in the original pack, protect from moisture and light.

Lidocaine can interact with several medications, altering its plasma concentration or enhancing toxicity.

Major Interactions (Avoid)

• Amiodarone: increases lidocaine levels, raising toxicity risk.
• Quinidine: potentiate cardiac effects and systemic toxicity.
• Procainamide: additive antiarrhythmic effects.
• Mexiletine: may cause cumulative neuro‑cardiac toxicity.
• Other amide‑type local anesthetics: risk of additive toxicity.

Moderate Interactions (Monitor Closely)

• CYP3A4 inhibitors (e.g., erythromycin, clarithromycin): may elevate lidocaine concentrations.
• CYP1A2 inhibitors (e.g., cimetidine): modest increase in plasma levels.
• Diuretics: can enhance hypotensive effects.
• General anesthetics (e.g., propofol, volatile agents): may deepen sedation.
• Beta‑blockers: may augment bradycardia when combined with lidocaine.