Lidocain Kreussler (Lidocaine Hydrochloride)

Lidocaine, the active ingredient in Lidocain Kreussler, acts on peripheral nerves to provide topical anesthesia in the oral cavity.

• Oral mucositis: reduces pain and facilitates oral intake during chemotherapy or radiotherapy‑induced mucosal injury.
• Sore throat: alleviates discomfort associated with acute pharyngitis or post‑viral irritation.
• Dental procedures: provides local anesthesia for minor extractions, scaling or other intra‑oral interventions.

• Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, stabilizing the inactive state of the channel and preventing depolarization. By inhibiting the influx of sodium ions, the drug halts the generation and propagation of action potentials along peripheral sensory fibers, resulting in reversible loss of sensation in the treated mucosal area. The effect is concentration‑dependent and typically begins within minutes of application, lasting for up to two hours depending on the dose and mucosal condition.

Lidocaine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Taste alteration: a temporary metallic or bitter taste in the mouth.
• Local burning or tingling: mild irritation at the application site.
• Numbness: transient loss of sensation in the oral mucosa.
• Dizziness or light‑headedness: occasional sensation of faintness.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or anaphylaxis in hypersensitive individuals.
• Cardiac arrhythmia: irregular heart rhythm, especially with excessive systemic absorption.
• Seizures: central nervous system excitation leading to convulsions.
• Methemoglobinemia: reduced oxygen‑carrying capacity of blood, presenting with cyanosis.

When using Lidocain Kreussler, several precautions should be observed to minimize risk.

• Assess allergy: verify the patient has no known hypersensitivity to lidocaine or amide‑type anesthetics.
• Limit dose: avoid exceeding the recommended maximum amount for oromucosal application.
• Hepatic impairment: use with caution in patients with liver disease, as lidocaine is metabolized hepatically.
• Cardiac conditions: monitor patients with pre‑existing arrhythmias or conduction disorders.
• Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Lidocain Kreussler can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

• Class I antiarrhythmics (e.g., quinidine, procainamide): may cause severe cardiac toxicity.
• Beta‑blockers in patients with conduction disease: increase risk of bradycardia and heart block.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): raise systemic lidocaine concentrations.

Moderate Interactions (Monitor Closely)

• CYP1A2 inducers (e.g., rifampicin, carbamazepine): may reduce lidocaine effectiveness.
• Epinephrine‑containing products: can prolong local anesthesia and affect cardiovascular response.
• Other local anesthetics: concurrent use may increase total local anesthetic load.