Product image of Lidocain/Prilocain Adgc (Lidocaine, Prilocaine) supplied by GNH India

Lidocain/Prilocain Adgc

Active Ingredient:
Lidocaine, Prilocaine
Origin:
EU

Lidocain/Prilocain Adgc (Lidocaine, Prilocaine)

Lidocaine and Prilocaine, the active ingredients in Lidocain/Prilocain Adgc, are local anesthetics presented as a topical formulation for skin and mucous membrane use. They provide reversible loss of sensation to facilitate minor procedures and reduce discomfort.

GNH India supplies Lidocain/Prilocain Adgc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is manufactured under EU GMP standards and distributed to meet the needs of healthcare providers across multiple regions.

Manufacturer / TM Owner

Zentiva Pharma Gmbh

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Indications & Clinical Uses

Lidocaine/Prilocaine is a topical local anesthetic used to temporarily block nerve transmission in the skin and mucous membranes.

  • Topical local anesthesia of skin and mucous membranes: provides numbing for minor diagnostic or therapeutic procedures.
  • Pain relief for minor surgical or diagnostic procedures: reduces discomfort during biopsies, suturing, or laser treatments.
  • Pre‑operative skin anesthesia: prepares the area before injection or minor surgery to improve patient comfort.

How It Works

  • Lidocaine and prilocaine act by reversibly binding to voltage‑gated sodium channels on neuronal membranes, stabilising the inactive state of the channel. This blocks the influx of sodium ions required for depolarisation, preventing initiation and propagation of nerve impulses and resulting in a temporary loss of sensation in the applied area.

Side Effects

Common Side Effects

  • Local irritation or erythema at the application site.
  • Mild burning or stinging sensation.
  • Itching or pruritus.
  • Swelling or edema of the treated area.
  • Transient numbness extending beyond the intended zone.

Serious or Rare Side Effects

  • Allergic contact dermatitis or severe skin reactions.
  • Methemoglobinemia, especially with extensive use.
  • Systemic toxicity presenting as CNS symptoms (dizziness, seizures) or cardiovascular depression.
  • Anaphylaxis or severe hypersensitivity reactions.
  • Persistent numbness or motor weakness.
  • Rare cases of tissue necrosis with improper use.

Precautions & Warnings

Lidocaine/Prilocaine should be used according to prescriber instructions and with awareness of the following precautions.

  • Allergy assessment: avoid in patients with known hypersensitivity to amide‑type local anesthetics.
  • Application area: limit to intact skin or mucosa; do not apply to open wounds or inflamed tissue.
  • Dosage control: adhere to recommended surface area and duration to prevent systemic absorption.
  • Patient populations: use cautiously in infants, elderly, or patients with hepatic impairment.
  • Concomitant anesthetics: avoid simultaneous use of other topical anesthetics to reduce cumulative toxicity.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidocaine/Prilocaine may interact with other medicines; awareness of the following is important.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): increased risk of methemoglobinemia.
  • Other systemic local anesthetics: additive risk of central nervous system and cardiovascular toxicity.
  • Sodium channel‑blocking antiarrhythmics: potential for enhanced cardiac effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia that signals systemic toxicity.
  • CYP450 inhibitors (e.g., cimetidine): may raise plasma concentrations of the anesthetics.
  • Alcohol: can potentiate central nervous system depression when systemic absorption occurs.

Frequently Asked Questions

Lidocain/Prilocain Adgc is a topical formulation that provides local anesthesia of the skin and mucous membranes. It is employed to numb the area before minor surgical or diagnostic procedures, to relieve pain during such interventions, and to prepare tissue for pre‑operative interventions.

Lidocaine, together with prilocaine, blocks voltage‑gated sodium channels in neuronal membranes. By stabilising the inactive state of these channels, the drugs prevent sodium influx, which stops the generation and conduction of nerve impulses, resulting in temporary loss of sensation at the site of application.

The appropriate dose and the area of application are determined by the prescribing healthcare professional based on the specific procedure, patient age, and clinical context. The product should be applied only as directed on the label or by the prescriber.

Safety data for this topical combination in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician after evaluating the individual situation.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lidocain/Prilocain Adgc combines two amide‑type anesthetics, offering a broader spectrum of nerve blockade and often a faster onset compared with single‑agent products such as lidocaine alone. The combination can provide deeper anesthesia for certain procedures while maintaining a safety profile comparable to other topical agents when used as directed.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from moisture, direct sunlight and extreme temperatures. Keep the container tightly closed when not in use to maintain product stability.

The product is applied topically to the intended skin or mucous membrane area. The prescribed amount is spread evenly over the surface, usually with a sterile applicator, and left in place for the duration specified by the healthcare professional before the procedure begins.

Serious risks include systemic toxicity leading to central nervous system symptoms (e.g., seizures, dizziness) or cardiovascular depression, as well as rare but severe allergic reactions such as anaphylaxis and methemoglobinemia. Patients should be monitored for signs of systemic absorption, especially when large surface areas are treated.

Individuals with a known hypersensitivity to lidocaine, prilocaine, or any amide‑type local anesthetic should avoid this product. It is also contraindicated on broken or inflamed skin, in patients with certain metabolic disorders that predispose to methemoglobinemia, and in situations where excessive systemic absorption could occur without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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