Lidocaina Aguettant (Lidocaine Hydrochloride)

• Lidocaine Hydrochloride is used as a local anesthetic for procedures requiring temporary nerve block.
• Minor surgical procedures: provides rapid loss of sensation to facilitate incision, excision or suturing with minimal discomfort.
• Dental procedures: numbs oral tissues to allow tooth extraction, cavity preparation or periodontal surgery without pain.
• Dermatologic procedures: anesthetizes skin for biopsies, excisions or laser treatments, improving patient tolerance.
• Intravenous regional anesthesia: blocks limb nerves when administered with a tourniquet, enabling surgery on the extremity without systemic analgesia.

• Lidocaine Hydrochloride exerts its effect by binding to the intracellular portion of voltage‑gated sodium channels in neuronal membranes. This binding stabilizes the channel in an inactivated state, preventing the influx of sodium ions during depolarization. Consequently, the generation and propagation of action potentials are inhibited, leading to a reversible loss of sensory and, at higher concentrations, motor nerve conduction in the administered area.

Lidocaine Hydrochloride may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Transient burning or stinging at the injection site
• Mild dizziness or light‑headedness
• Nausea or vomiting
• Localized swelling or erythema

Serious or Rare Side Effects

• Systemic toxicity presenting as seizures or cardiac arrhythmias
• Severe allergic reactions including anaphylaxis
• Methemoglobinemia causing cyanosis
• Persistent numbness or motor weakness beyond the expected duration

• When using Lidocaina Aguettant, several precautions should be observed to ensure patient safety and product integrity.
• Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics
• Dose calculation: base total dose on patient weight and maximum recommended limits
• Cardiac monitoring: observe for signs of arrhythmia in patients with pre‑existing heart disease
• Use with caution in hepatic impairment: reduced metabolism may increase systemic exposure
• Avoid intravascular injection: aspirate before administration to prevent rapid systemic absorption
• Store at ambient temperature: keep below 25°C, protect from moisture and light in the original packaging

Lidocaine Hydrochloride can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

• Class I antiarrhythmics (e.g., quinidine, procainamide): may potentiate cardiotoxic effects
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase plasma lidocaine concentrations

Moderate Interactions (Monitor Closely)

• Beta‑blockers (e.g., propranolol): may enhance bradycardia when combined with lidocaine
• Other local anesthetics: cumulative dosing can raise risk of systemic toxicity
• Diuretics (e.g., furosemide): may reduce plasma protein binding, modestly increasing free lidocaine