Lidocaina Cloridrato E Idrocortisone Acetato Marco Viti (Hydrocortisone Acetate, Lidocaine Hydrochloride)

Lidocaine Hydrochloride and Hydrocortisone Acetate act locally on the rectal mucosa to alleviate pain and inflammation.

• Rectal pain: provides rapid analgesia by numbing sensory nerves in the affected area.
• Inflammatory rectal mucosa: reduces swelling and erythema through corticosteroid action.
• Hemorrhoidal discomfort: eases itching and burning associated with mild hemorrhoidal irritation.

• Lidocaine Hydrochloride blocks voltage‑gated sodium channels on peripheral nerve membranes, preventing depolarisation and halting pain signal transmission. Hydrocortisone Acetate penetrates cells and binds glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, reduce vascular permeability, and inhibit leukocyte migration, thereby diminishing local inflammation.

Adverse reactions may occur at the application site or systemically after absorption.

Common Side Effects

• Mild burning or stinging sensation at the site of application.
• Local itching or mild rash.
• Transient redness or mild swelling.
• Temporary numbness extending slightly beyond the treated area.
• Mild headache.
• Slight taste disturbance if product contacts oral mucosa.

Serious or Rare Side Effects

• Allergic reaction with swelling, hives, or difficulty breathing.
• Severe skin ulceration or necrosis at the application site.
• Systemic corticosteroid effects such as adrenal suppression.
• Secondary infection of the rectal mucosa.
• Significant electrolyte imbalance from systemic absorption.
• Unexplained fever or systemic infection signs.

Before using this rectal preparation, consider the following safety measures.

• Assess for hypersensitivity: avoid use in patients with known allergy to lidocaine or corticosteroids.
• Limit duration of use: prolonged application may increase risk of systemic corticosteroid exposure.
• Avoid in active infection: the product may mask symptoms and delay treatment.
• Use with caution in patients with diabetes: corticosteroid may affect glucose control.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Potential drug interactions should be reviewed prior to therapy.

Major Interactions (Avoid)

• Systemic corticosteroids: additive immunosuppression may increase infection risk.
• Topical antibiotics: may enhance systemic absorption leading to toxicity.
• Other local anesthetics: risk of cumulative nerve block and systemic toxicity.
• Monoamine oxidase inhibitors: possible severe hypotension if systemic absorption occurs.
• Anticoagulants: increased risk of bleeding with mucosal irritation.

Moderate Interactions (Monitor Closely)

• Diabetes medications: corticosteroid component may raise blood glucose levels.
• Antihistamines: may mask early signs of an allergic reaction.
• Non‑steroidal anti‑inflammatory drugs: additive gastrointestinal irritation.
• Immunosuppressants: may enhance local immunosuppression.
• Vaccines: topical steroids may reduce local immune response to live vaccines.