Lidocaina Cloridrato Intes (Lidocaine Hydrochloride)

Lidocaine Hydrochloride is used as a topical ophthalmic anesthetic to temporarily numb the surface of the eye for various procedures.

• Corneal anesthesia: enables painless examination or removal of foreign bodies from the cornea.
• Intra‑ocular surgery preparation: provides short‑term numbness during cataract or laser procedures.
• Diagnostic testing: facilitates comfortable ocular pressure measurements and fluorescein staining.
• Minor ocular trauma care: reduces pain during cleaning and dressing of superficial eye injuries.

• Lidocaine Hydrochloride reversibly blocks voltage‑gated sodium channels on peripheral nerve membranes, preventing the initiation and propagation of action potentials. By inhibiting sodium influx, it halts nerve impulse conduction in the corneal and conjunctival sensory fibers, resulting in temporary loss of sensation in the ocular surface.

Lidocaine Hydrochloride may cause local and systemic adverse reactions when applied to the eye.

Common Side Effects

• Burning or stinging sensation upon instillation.
• Transient redness or conjunctival hyperemia.
• Tearing or increased lacrimation.
• Temporary blurred vision.
• Mild allergic conjunctivitis.
• Sensation of foreign body in the eye.

Serious or Rare Side Effects

• Corneal epithelial defect or ulceration.
• Severe allergic reaction, including angioedema or anaphylaxis.
• Persistent visual impairment.
• Toxic systemic effects if excessive absorption occurs.
• Secondary infection of the ocular surface.

When using Lidocaina Cloridrato Intes, consider the following safety measures.

• Allergy assessment: avoid use in patients with known hypersensitivity to lidocaine or amide‑type anesthetics.
• Corneal disease: use with caution in eyes with existing epithelial defects or keratitis.
• Duration of use: limit application to the shortest time necessary; avoid repeated dosing without medical supervision.
• Systemic exposure: monitor infants and patients with compromised hepatic function for signs of systemic toxicity.
• Interaction with other eye drops: separate administration times to reduce local irritation.
• Store at room temperature: keep in the original container, protect from light and moisture.

Lidocaina Cloridrato Intes may interact with other medications applied to the eye or systemically absorbed.

Major Interactions (Avoid)

• Concurrent systemic lidocaine therapy: risk of cumulative toxicity.
• Other topical ocular anesthetics: additive local anesthetic effect may increase corneal toxicity.
• Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise systemic lidocaine levels.

Moderate Interactions (Monitor Closely)

• Beta‑blocker eye drops: may potentiate local cardiovascular effects if absorbed.
• Antihistamine eye preparations: could alter ocular surface tolerance.
• Alcohol‑containing solutions: may increase irritation and systemic absorption.