Product image of Lidocaina Cloridrato S.A.L.F. (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lidocaina Cloridrato S.A.L.F.

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lidocaina Cloridrato S.A.L.F. (Lidocaine Hydrochloride Monohydrate)

Lidocaine, the active ingredient in Lidocaina Cloridrato S.A.L.F., is a local anesthetic presented as a sterile injectable solution for intravenous use. It provides local and regional anesthesia and is also employed in the treatment of ventricular arrhythmias in appropriate patients.

GNH India supplies Lidocaina Cloridrato S.A.L.F. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

Lidocaine is used in clinical settings to achieve anesthesia or to manage cardiac rhythm disturbances.

  • Local anesthesia: provides rapid loss of sensation for minor surgical or diagnostic procedures.
  • Regional anesthesia: enables nerve block techniques for surgeries requiring extensive analgesia.
  • Ventricular arrhythmias: suppresses abnormal ventricular electrical activity in emergency cardiac care.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal and cardiac cell membranes, stabilizing the inactive state of the channel. This inhibition prevents the initiation and propagation of action potentials, thereby reducing nerve impulse conduction and suppressing abnormal cardiac depolarizations.

Side Effects

Adverse reactions may occur with lidocaine administration.

Common Side Effects

  • Tingling or numbness at the injection site
  • Dizziness or light‑headedness
  • Nausea or metallic taste
  • Transient hypotension

Serious or Rare Side Effects

  • Seizures or convulsions
  • Cardiac arrest or severe arrhythmia
  • Anaphylactic or severe allergic reaction
  • Methemoglobinemia
  • Respiratory depression

Precautions & Warnings

Lidocaine should be used with careful clinical monitoring.

  • Cardiac assessment: evaluate baseline rhythm and conduction before infusion.
  • Blood pressure monitoring: watch for hypotension during administration.
  • Hypersensitivity: avoid in patients with known lidocaine allergy.
  • Hepatic function: use caution in severe liver impairment as metabolism may be reduced.
  • Elderly patients: consider dose reduction due to altered pharmacokinetics.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lidocaine may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Class I anti‑arrhythmics (e.g., quinidine): may increase cardiotoxicity.
  • Amiodarone: can potentiate lidocaine plasma levels.
  • CYP3A4 inhibitors (e.g., erythromycin, ketoconazole): raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may modestly increase lidocaine concentrations.
  • Carbamazepine: can reduce lidocaine effectiveness by inducing metabolism.
  • Propofol: concurrent use may enhance central nervous system depression.

Frequently Asked Questions

Lidocaina Cloridrato S.A.L.F. contains lidocaine, which is employed to produce local or regional anesthesia for surgical and diagnostic procedures and to treat life‑threatening ventricular arrhythmias in emergency cardiac care.

Lidocaine blocks voltage‑gated sodium channels on nerve and cardiac cells, preventing the rapid influx of sodium ions needed for action potential generation. This stops nerve impulse transmission and stabilizes abnormal cardiac electrical activity.

The specific dose of lidocaine is determined by the prescribing clinician based on the indication, patient weight, age, and clinical condition. Dosing regimens are individualized and should follow the prescriber’s instructions.

Safety data for lidocaine in pregnancy and lactation are limited, and the pregnancy category is unknown. Use only if the potential benefit justifies any potential risk to the fetus or infant, and consult a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lidocaine has a rapid onset and moderate duration compared with agents such as bupivacaine (longer duration) or procaine (shorter onset). Its pharmacokinetic profile and safety margin make it a common choice for both short procedures and cardiac arrhythmia management.

Lidocaina Cloridrato S.A.L.F. should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the vial from moisture, direct sunlight and extreme temperature fluctuations to maintain stability.

Lidocaine is administered intravenously as a sterile solution. The route, rate of infusion and total dose are determined by the treating physician and may be adjusted according to the clinical response and monitoring results.

Serious risks include seizures, severe cardiac arrhythmias, cardiac arrest, anaphylaxis, methemoglobinemia and respiratory depression. Prompt recognition and supportive measures are essential if any of these events occur.

Patients with known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe hepatic impairment, and individuals with certain cardiac conduction disorders should avoid lidocaine unless a specialist determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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