Lidocaina E Prilocaina Teva (Lidocaine, Prilocaine)

Lidocaina E Prilocaina acts on peripheral nerve sodium channels to provide topical anesthesia for skin‑related procedures.

• Minor skin procedures: produces rapid, reversible loss of sensation for biopsies, laser treatments, or minor excisions.
• Superficial wound pain relief: reduces discomfort from cuts, abrasions, or burns.
• Pre‑operative skin anesthesia: numbs the skin before surgical incision or injection.
• Dermatologic procedures: facilitates painless application of topical agents during cosmetic or therapeutic treatments.
• Cosmetic injections: provides local numbness for filler or toxin administration.

• Lidocaine and prilocaine block neuronal voltage‑gated sodium channels in a reversible manner, preventing depolarization and the propagation of nerve impulses. By stabilizing the neuronal membrane, they inhibit the initiation and conduction of pain signals in the peripheral nerves at the site of topical application, resulting in localized loss of sensation without systemic anesthetic effects when used as directed.

Common Side Effects

• Transient erythema: mild redness at the application site.
• Burning sensation: brief feeling of warmth or stinging.
• Pruritus: occasional itching of the treated area.
• Localized swelling: mild edema limited to the site.
• Tingling: temporary pins‑and‑needles feeling.

Serious or Rare Side Effects

• Allergic contact dermatitis: severe skin reaction with rash and itching.
• Systemic toxicity: signs such as seizures, cardiac arrhythmia, or altered mental status if excessive absorption occurs.
• Severe skin necrosis: rare tissue death at the application site.
• Methemoglobinemia: uncommon blood disorder causing cyanosis.
• Anaphylaxis: rare life‑threatening allergic response.

Before using Lidocaina E Prilocaina, consider the following precautions.

• Allergy assessment: avoid in patients with known hypersensitivity to lidocaine, prilocaine, or other amide anesthetics.
• Application area: limit use to intact, non‑inflamed skin and avoid mucous membranes.
• Duration of exposure: do not exceed the recommended contact time to reduce systemic absorption.
• Concomitant anesthetics: avoid simultaneous use of other topical anesthetic products to prevent additive toxicity.
• Pediatric use: apply with caution in children and follow prescriber guidance regarding dose and area.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Lidocaina E Prilocaina may interact with other medications that affect cardiac or nervous system function.

Major Interactions (Avoid)

• Systemic local anesthetics: concurrent use of injectable lidocaine can increase total anesthetic load and risk of toxicity.
• Class I antiarrhythmics (e.g., quinidine): may enhance cardiotoxic effects of absorbed anesthetic.
• Strong CYP3A4 inhibitors: can raise systemic levels of prilocaine, increasing adverse effect risk.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: may potentiate cardiac depression if systemic absorption occurs.
• Diuretics: can alter plasma concentration of local anesthetics, requiring observation.