Product image of Lidocaine Accord Healthcare (Lidocaine Hydrochloride) supplied by GNH India

Lidocaine Accord Healthcare

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Lidocaine Accord Healthcare (Lidocaine Hydrochloride)

Lidocaine, the active ingredient in Lidocaine Accord Healthcare, is a local anesthetic presented as a sterile injectable solution for infiltration and intravenous use. It provides local infiltration anesthesia, nerve block anesthesia, and intravenous anti‑arrhythmic therapy in surgical and cardiac settings.

GNH India supplies Lidocaine Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Lidocaine is used to produce reversible loss of sensation in tissues by blocking sodium channels, making it valuable for several clinical applications.

  • Local infiltration anesthesia: provides numbing of targeted tissue for minor surgical or diagnostic procedures.
  • Nerve block anesthesia: enables regional anesthesia for surgical or diagnostic interventions requiring prolonged analgesia.
  • Intravenous anti‑arrhythmic therapy: used to manage certain cardiac arrhythmias by stabilizing myocardial electrical activity.

How It Works

  • Lidocaine exerts its effect by reversibly binding to voltage‑gated sodium channels on neuronal membranes, preventing the influx of sodium ions during depolarization. This blockade inhibits the initiation and propagation of action potentials, resulting in loss of sensation in the targeted area and stabilization of cardiac electrical conduction when administered intravenously.

Side Effects

Adverse reactions may occur following administration of lidocaine. The frequency and severity vary with dose, route, and patient factors.

Common Side Effects

  • Tingling or numbness at the injection site
  • Mild hypotension
  • Dizziness or light‑headedness

Serious or Rare Side Effects

  • Methemoglobinemia
  • Severe cardiac conduction disturbances, including bradycardia or heart block
  • Anaphylactic reaction or severe allergic response

Precautions & Warnings

Lidocaine should be used with careful clinical assessment and monitoring to minimize risks.

  • Cardiac history: evaluate for pre‑existing conduction abnormalities before use.
  • Blood pressure: monitor for hypotension during and after administration.
  • Allergy: avoid in patients with known lidocaine hypersensitivity.
  • Hepatic function: adjust use in patients with significant liver impairment.
  • Elderly patients: consider reduced dosage due to altered pharmacokinetics.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidocaine may interact with other medications, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): may increase risk of cardiac toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise lidocaine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may potentiate bradycardic effects.
  • Calcium channel blockers: can enhance negative inotropic actions.
  • Diuretics causing electrolyte imbalance: may predispose to arrhythmias when combined with lidocaine.

Frequently Asked Questions

Lidocaine Accord Healthcare is a sterile injectable form of lidocaine used for local infiltration anesthesia, regional nerve block procedures, and as an intravenous anti‑arrhythmic agent to manage certain cardiac rhythm disturbances.

Lidocaine blocks voltage‑gated sodium channels on nerve and cardiac cells, preventing sodium influx during depolarization. This stops the generation and spread of action potentials, resulting in loss of sensation in the treated area and stabilisation of abnormal cardiac electrical activity.

The appropriate dose of lidocaine is determined by the prescribing clinician based on the intended indication, route of administration, patient weight, age, and clinical condition. Dosage recommendations are provided in the product’s prescribing information and must be individualized.

Safety data for lidocaine in pregnancy are limited, and the product is classified as pregnancy category unknown. It should be used only if the potential benefit justifies any potential risk to the fetus. Lidocaine is excreted in breast milk; caution is advised when administering to nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Lidocaine is a medium‑duration amide‑type local anesthetic with a rapid onset, making it suitable for many infiltration and nerve‑block procedures. Compared with shorter‑acting agents like procaine, lidocaine provides longer analgesia, while agents such as bupivacaine offer even longer duration but have a higher risk of cardiotoxicity.

Lidocaine Accord Healthcare should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from direct sunlight, moisture, and extreme temperature fluctuations to maintain sterility and potency.

Lidocaine is administered by infiltration into the target tissue, as a regional nerve block, or intravenously for anti‑arrhythmic therapy. The route, injection technique, and volume are determined by the clinician based on the specific clinical indication and patient factors.

Serious risks include systemic toxicity manifesting as methemoglobinemia, severe cardiac conduction disturbances (e.g., bradycardia, heart block), seizures, respiratory depression, and anaphylactic reactions. Prompt recognition and supportive management are essential if toxicity occurs.

Lidocaine should be avoided in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, in those with severe hepatic impairment, and in individuals with certain cardiac conduction disorders unless specifically indicated and closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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