Product image of Lidocaine/Adrenaline Normon (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocaine/Adrenaline Normon

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocaine/Adrenaline Normon (Epinephrine, Lidocaine Hydrochloride)

Lidocaine, the active ingredient in Lidocaine/Adrenaline Normon, is a local anesthetic presented as an injectable solution for infiltration and perineural use. It provides rapid onset anesthesia for minor surgical, dental and peripheral nerve block procedures in adult patients.

GNH India supplies Lidocaine/Adrenaline Normon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Normon, S.A.

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Indications & Clinical Uses

Lidocaine/Adrenaline Normon is a local anesthetic with vasoconstrictor used in procedures that require short‑term numbness and reduced bleeding.

  • Minor surgical procedures: provides rapid, localized anesthesia and limits intra‑operative bleeding.
  • Dental procedures: enables painless tooth extractions, restorations and periodontal surgery.
  • Peripheral nerve blocks: facilitates regional anesthesia for limb surgeries and postoperative analgesia.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and impulse transmission. Epinephrine activates α‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that prolongs lidocaine’s effect, reduces systemic absorption, and limits local bleeding.

Side Effects

Adverse reactions may range from mild, transient events to serious, life‑threatening conditions.

Common Side Effects

  • Pain or burning at the injection site
  • Transient tachycardia or palpitations
  • Mild hypertension
  • Nausea or vomiting
  • Dizziness or light‑headedness
  • Metallic taste in the mouth

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Cardiac arrhythmias or myocardial ischemia
  • Central nervous system toxicity (seizures, loss of consciousness)
  • Prolonged hypotension
  • Systemic lidocaine toxicity (CNS depression, respiratory arrest)
  • Vascular complications (ischemia of distal tissues).

Precautions & Warnings

When using Lidocaine/Adrenaline Normon, clinicians should observe specific safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart rhythm before administration.
  • Hypertension caution: avoid high‑dose epinephrine in uncontrolled hypertensive patients.
  • Hypersensitivity: do not use in individuals with known allergy to lidocaine, epinephrine or related compounds.
  • Systemic toxicity monitoring: watch for signs of CNS or cardiac toxicity during and after injection.
  • Dose adjustment: consider lower doses for pediatric, geriatric or low‑body‑weight patients.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lidocaine/Adrenaline Normon can interact with several drug classes, affecting cardiovascular or metabolic stability.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may potentiate hypertensive response to epinephrine.
  • Non‑selective β‑blockers: can exacerbate epinephrine‑induced hypertension and reduce tachycardia.
  • Tricyclic antidepressants: increase risk of cardiac arrhythmias.
  • Other vasoconstrictors (e.g., phenylephrine): may cause severe hypertension.
  • Class I anti‑arrhythmic agents: additive cardiotoxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, heparin): monitor bleeding due to vasoconstriction effects.
  • CYP3A4 inhibitors (cimetidine, erythromycin): may raise plasma lidocaine levels.
  • Diuretics: may alter electrolyte balance influencing lidocaine toxicity.
  • Sympathomimetic drugs (e.g., pseudoephedrine): monitor blood pressure.
  • Local anesthetic mixtures: assess cumulative lidocaine dose.

Frequently Asked Questions

Lidocaine/Adrenaline Normon is an injectable solution that provides local anesthesia combined with a vasoconstrictor. It is used to numb tissue and reduce bleeding during minor surgical procedures, dental work, and peripheral nerve blocks.

Lidocaine blocks voltage‑gated sodium channels on nerve fibers, preventing the generation and propagation of action potentials. This interruption stops pain signals from reaching the brain, producing a rapid loss of sensation in the targeted area.

The specific dose is determined by the prescribing clinician based on the procedure, patient size, and clinical judgment. Healthcare professionals calculate the appropriate volume and concentration to achieve effective anesthesia while maintaining safety.

Safety data for use in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Lidocaine/Adrenaline Normon combines lidocaine’s rapid onset and moderate duration with epinephrine’s vasoconstrictive effect, which prolongs anesthesia and reduces bleeding. Compared with plain lidocaine, the addition of epinephrine offers longer analgesia and better hemostasis, while other agents like bupivacaine provide longer duration but slower onset.

Store the injectable solution at room temperature, below 25 °C, in its original packaging. Protect it from moisture, direct sunlight and extreme temperatures. Do not freeze the product, and inspect the vial for particulate matter before use.

The solution is administered by infiltration or perineural injection using a sterile syringe and needle. The clinician injects the drug directly into the target tissue or around the nerve under aseptic technique, adjusting volume according to the size of the area to be anesthetized.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias, myocardial ischemia, central nervous system toxicity such as seizures, and profound hypotension. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, certain cardiac conduction disorders, or those taking MAO inhibitors without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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