Product image of Lidocaine Fresenius Kabi (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lidocaine Fresenius Kabi

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lidocaine Fresenius Kabi (Lidocaine Hydrochloride Monohydrate)

Lidocaine Hydrochloride Monohydrate, the active ingredient in Lidocaine Fresenius Kabi, is a local anesthetic presented as a sterile injectable solution for epidural, intramuscular and intravenous use. It provides rapid onset nerve block for minor surgical procedures, epidural analgesia, and ventricular arrhythmia control in adult patients and can be administered by trained healthcare professionals.

GNH India supplies Lidocaine Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide and clinics across multiple continents with reliable cold‑chain logistics where required.

Manufacturer / TM Owner

Fresenius Kabi Nv/Sa

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Indications & Clinical Uses

Lidocaine is used in several clinical settings that require rapid, reversible nerve blockade.

  • Minor surgical procedures: provides local anesthesia to numb the operative area.
  • Epidural analgesia: delivers analgesia for labor, postoperative pain, or chronic pain management.
  • Ventricular arrhythmias: used intravenously to suppress abnormal cardiac electrical activity.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal and cardiac cell membranes, stabilizing the inactive state of the channel. This reversible inhibition prevents the rapid influx of sodium ions required for depolarization, thereby halting the propagation of nerve impulses and reducing ectopic cardiac conduction. By limiting the rise of intracellular sodium, lidocaine also diminishes calcium overload, contributing to its anti‑arrhythmic properties.

Side Effects

Lidocaine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tingling or numbness at the injection site.
  • Metallic taste.
  • Dizziness.
  • Mild hypotension.

Serious or Rare Side Effects

  • Seizures.
  • Severe cardiac arrhythmias (e.g., ventricular tachycardia).
  • Allergic reactions including anaphylaxis.

Precautions & Warnings

When using lidocaine, several safety considerations should be observed.

  • Cardiac assessment: evaluate baseline ECG and heart function before use.
  • Hepatic impairment: reduce dose or monitor closely in patients with liver disease.
  • Allergy history: avoid in individuals with known lidocaine or amide‑type anesthetic hypersensitivity.
  • Elderly patients: use lower initial doses due to decreased clearance.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidocaine interacts with several drug classes; awareness of major and moderate interactions helps prevent adverse events.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): additive cardiac toxicity.
  • Beta‑blockers (e.g., propranolol): risk of severe bradycardia and hypotension.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase lidocaine plasma levels.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative nerve toxicity.
  • Diuretics (e.g., furosemide): may enhance lidocaine’s effect on cardiac conduction.
  • Calcium channel blockers (e.g., verapamil): may potentiate hypotensive effects.

Frequently Asked Questions

Lidocaine Fresenius Kabi is a sterile injectable solution of lidocaine hydrochloride monohydrate used to provide local anesthesia for minor surgical procedures, to deliver epidural analgesia for labor or postoperative pain, and to treat ventricular arrhythmias when administered intravenously.

Lidocaine works by reversibly blocking voltage‑gated sodium channels on nerve and cardiac cells, preventing the rapid influx of sodium that is necessary for depolarisation. This stops the propagation of nerve impulses and suppresses abnormal cardiac electrical activity, producing anaesthesia and anti‑arrhythmic effects.

The dose is set by the prescribing clinician based on the intended indication, route of administration, patient weight, age, organ function and any concurrent medications. Standard dosing regimens are not provided here because they must be individualized for safety and efficacy.

Lidocaine’s pregnancy category is listed as unknown. It should only be used during pregnancy or lactation when the potential benefit justifies any potential risk to the fetus or infant, and under the guidance of a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Both lidocaine and bupivacaine are amide‑type local anesthetics, but lidocaine has a faster onset and a shorter duration of action, making it suitable for short procedures. Bupivacaine provides a longer block but carries a higher risk of cardiotoxicity at comparable plasma concentrations.

Lidocaine Fresenius Kabi should be stored at room temperature, below 25 °C, in its original packaging. Protect the vials from light, moisture and extreme temperatures. Do not freeze. Inspect the solution for particulate matter or discoloration before use.

The product is supplied as a sterile solution for injection. It can be administered epidurally, intramuscularly or intravenously by a qualified healthcare professional, using aseptic technique and appropriate dosing calculations for the chosen route.

Serious risks include seizures, severe cardiac arrhythmias such as ventricular tachycardia, profound hypotension or cardiovascular collapse, respiratory depression, and allergic reactions that may progress to anaphylaxis. Immediate medical attention is required if any of these events occur.

Lidocaine should be avoided in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, in those with severe hepatic impairment without dose adjustment, and in individuals with certain cardiac conduction disorders where sodium‑channel blockade could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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