Lidocaína 1% Braun (Lidocaine Hydrochloride)

• Lidocaine is a local anesthetic used to achieve temporary loss of sensation in targeted tissues.
• Epidural anesthesia: provides analgesia for labor, cesarean sections and lower‑body surgeries.
• Intradermal anesthesia: enables painless skin biopsies, dermal filler placement and minor dermatologic procedures.
• Subcutaneous anesthesia: facilitates minor surgical incisions and suturing by numbing the tissue beneath the skin.

• Lidocaine reversibly blocks voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel and preventing the rapid influx of sodium ions required for depolarization. This inhibition halts the generation and propagation of nerve impulses, producing a localized loss of sensation without affecting surrounding tissues.

Lidocaine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Tingling or numbness at the injection site
• Mild swelling or erythema around the administration area
• Dizziness or light‑headedness
• Metallic taste in the mouth

Serious or Rare Side Effects

• Cardiac arrhythmias, including ventricular tachycardia
• Severe hypotension or cardiovascular collapse
• Seizures or central nervous system toxicity
• Allergic reactions such as rash, bronchospasm, or anaphylaxis
• Methemoglobinemia leading to cyanosis
• Respiratory depression requiring airway support

• Before using Lidocaína 1% Braun, consider the following safety measures.
• Allergy assessment: verify no known hypersensitivity to lidocaine or other amide‑type anesthetics.
• Cardiac risk: use caution in patients with existing heart block, arrhythmias, or severe conduction disorders.
• Dose limitation: avoid exceeding recommended cumulative doses to reduce toxicity risk.
• CNS monitoring: observe for signs of central nervous system excitation or depression during and after administration.
• Hepatic function: adjust dosing in patients with significant liver impairment as metabolism may be reduced.
• Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Lidocaine can interact with several medicines, altering its plasma concentration or enhancing toxicity.

Major Interactions (Avoid)

• Amiodarone: potent CYP3A4 inhibition increases lidocaine levels.
• Cimetidine: reduces hepatic clearance, raising systemic exposure.
• Erythromycin: may elevate plasma concentrations through metabolic inhibition.
• Mexiletine: additive sodium‑channel blockade can precipitate toxicity.
• Class I antiarrhythmics (e.g., quinidine, procainamide): synergistic cardiac effects.

Moderate Interactions (Monitor Closely)

• Beta‑adrenergic blockers: may mask early signs of lidocaine toxicity.
• Calcium channel blockers: can enhance negative inotropic effects.
• Diuretics (especially thiazides): may lower serum albumin, increasing free drug.
• General anesthetics (e.g., propofol, volatile agents): monitor for additive CNS depression.
• Opioids: heightened risk of respiratory depression when combined.