Product image of Lidocaïnehydrochloride 10 Mg/Ml, Injectievloeistof (Lidocaine Hydrochloride) supplied by GNH India

Lidocaïnehydrochloride 10 Mg/Ml, Injectievloeistof

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Lidocaïnehydrochloride 10 Mg/Ml, Injectievloeistof (Lidocaine Hydrochloride)

Lidocaine Hydrochloride, the active ingredient in Lidocaïnehydrochloride 10 Mg/Ml, Injectievloeistof, is a local anesthetic presented as a 10 mg/mL injectable solution for intravenous use. It provides reversible nerve impulse blockade for local anesthesia during minor surgical procedures, nerve block techniques, and management of ventricular arrhythmias.

GNH India supplies Lidocaïnehydrochloride 10 Mg/Ml, Injectievloeistof as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Nederland B.V.

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Indications & Clinical Uses

Lidocaine Hydrochloride is used in the management of pain and cardiac rhythm disorders through sodium‑channel blockade.

  • Minor surgical procedures: provides rapid local anesthesia to enable pain‑free operations.
  • Nerve block anesthesia: produces targeted regional numbness for diagnostic or therapeutic interventions.
  • Ventricular arrhythmias: stabilises cardiac electrical activity during acute arrhythmic episodes.

How It Works

  • Lidocaine Hydrochloride reversibly binds to voltage‑gated sodium channels on neuronal and cardiac cell membranes, inhibiting the influx of sodium ions. This prevents the initiation and propagation of action potentials, resulting in loss of sensation in peripheral nerves and stabilization of cardiac depolarisation, thereby producing local anaesthesia and anti‑arrhythmic effects.

Side Effects

Lidocaine Hydrochloride may cause a range of adverse reactions, most of which are dose‑related and transient.

Common Side Effects

  • Tingling or numbness at the injection site.
  • Transient dizziness or light‑headedness.
  • Metallic taste in the mouth.
  • Mild headache.
  • Nausea.

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse.
  • Cardiac arrhythmias, including ventricular tachycardia.
  • Anaphylactic or severe allergic reaction.
  • Central nervous system toxicity (e.g., seizures, loss of consciousness).

Precautions & Warnings

When using Lidocaine Hydrochloride, careful assessment and monitoring are essential to minimise risks.

  • Assess allergy history: confirm no known hypersensitivity to amide‑type local anesthetics.
  • Monitor cardiovascular status: observe blood pressure and heart rhythm during administration.
  • Use incremental dosing: inject slowly to reduce systemic toxicity.
  • Avoid intravascular injection: aspirate before each dose.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lidocaine Hydrochloride can interact with several drug classes, requiring attention to avoid enhanced toxicity.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase systemic toxicity.
  • Beta‑blockers (e.g., propranolol): can exacerbate cardiac depression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma lidocaine levels.

Moderate Interactions (Monitor Closely)

  • Concurrent use with other local anesthetics: additive toxicity risk.
  • General anesthetics (e.g., propofol): may potentiate central nervous system depression.
  • Diuretics (e.g., furosemide): may alter plasma protein binding and affect lidocaine concentration.

Frequently Asked Questions

Lidocaïnehydrochloride 10 mg/mL injectable is a sterile solution of lidocaine hydrochloride used to provide local anesthesia for minor surgical procedures, to perform regional nerve block anesthesia, and to manage ventricular arrhythmias by stabilising cardiac electrical activity.

Lidocaine hydrochloride works by reversibly binding to voltage‑gated sodium channels on nerve and cardiac cells, blocking sodium influx. This inhibition prevents the generation and propagation of action potentials, producing loss of sensation in the targeted area and stabilising abnormal cardiac rhythms.

The appropriate dose of Lidocaïnehydrochloride 10 mg/mL is determined by the prescribing clinician based on the specific procedure, patient characteristics, and therapeutic goal. Dosage calculations are performed by the healthcare professional and are not provided here.

The safety of lidocaine hydrochloride in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Lidocaine is an amide‑type local anesthetic with a rapid onset and moderate duration, making it suitable for short‑ to medium‑length procedures. Compared with ester‑type agents such as procaine, lidocaine has a lower incidence of allergic reactions and a more predictable pharmacokinetic profile.

Lidocaïnehydrochloride 10 mg/mL injectable should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain sterility.

The solution is administered intravenously or by targeted injection under aseptic conditions. The prescriber determines the injection site, volume, and rate of administration, ensuring aspiration before each dose to avoid intravascular delivery.

Serious risks include severe hypotension, cardiac arrhythmias, central nervous system toxicity such as seizures, and rare anaphylactic reactions. Prompt recognition and supportive management are essential if these events occur.

Patients with known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe heart block, uncontrolled heart failure, or significant hepatic impairment should avoid this medication unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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