Lidocaïnehydrochloride 20 Mg/Ml, Injectievloeistof (Lidocaine Hydrochloride)

Lidocaine hydrochloride blocks voltage‑gated sodium channels on neuronal and cardiac membranes, stabilising them in an inactive state. This prevents the rapid influx of sodium ions needed for depolarisation, thereby inhibiting nerve impulse transmission and reducing abnormal cardiac excitability.

The appropriate dose of lidocaine hydrochloride is determined by the prescribing clinician based on the specific procedure, patient characteristics, and route of administration. Dosage may vary widely, and the prescriber sets the exact amount to ensure safety and efficacy.

Safety data for lidocaine hydrochloride in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

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Lidocaine is an amide‑type local anesthetic with a rapid onset and moderate duration, often compared with bupivacaine, which has a longer duration but slower onset. Compared with ester‑type anesthetics, lidocaine has a lower risk of allergic reactions and a well‑characterised safety profile.

Lidocaïnehydrochloride 20 Mg/Ml, Injectievloeistof should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the container in its original packaging until use to maintain sterility.

Lidocaine is administered by intravenous injection for cardiac indications or by infiltration, nerve block, or epidural techniques for local anesthesia. The injection is performed by a qualified healthcare professional using aseptic technique, and the volume is drawn from the sterile vial immediately before use.

Serious risks include severe allergic reactions (anaphylaxis), cardiac conduction disturbances such as bradycardia or heart block, methemoglobinemia, central nervous system toxicity leading to seizures or loss of consciousness, and respiratory depression. Immediate medical attention is required if any of these occur.

Lidocaine should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, severe heart block, uncontrolled hypotension, or those taking class I antiarrhythmic drugs that could increase cardiotoxicity. It should also be used with caution in patients with significant hepatic impairment.