Product image of Lidocaine Hydrochloride Laboratoire Aguettant (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lidocaine Hydrochloride Laboratoire Aguettant

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lidocaine Hydrochloride Laboratoire Aguettant (Lidocaine Hydrochloride Monohydrate)

Lidocaine Hydrochloride, the active ingredient in Lidocaine Hydrochloride Laboratoire Aguettant, is a local anesthetic presented as a sterile solution for epidural, infiltration, intravenous, and subcutaneous use. It provides local anesthesia for minor surgical or dental procedures, epidural analgesia during labor or surgery, intravenous antiarrhythmic therapy, and peripheral nerve block.

GNH India supplies Lidocaine Hydrochloride Laboratoire Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Lidocaine Hydrochloride is used to provide local anesthesia and analgesia across several clinical pathways.

  • Minor surgical or dental procedures: provides rapid, reversible loss of sensation at the targeted site.
  • Epidural analgesia during labor or surgery: delivers continuous pain relief while preserving consciousness.
  • Intravenous antiarrhythmic therapy: stabilises cardiac rhythm in certain arrhythmias.
  • Peripheral nerve block: produces regional anesthesia for limb surgeries.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the influx of sodium ions required for depolarisation. This inhibition stops the initiation and propagation of nerve impulses, resulting in a reversible loss of sensation in the area where the drug is applied or injected.

Side Effects

Adverse reactions to lidocaine may vary in frequency and severity.

Common Side Effects

  • Burning or tingling at the injection site.
  • Light‑headedness or dizziness.
  • Nausea.
  • Metallic taste.
  • Mild hypotension.
  • Headache.

Serious or Rare Side Effects

  • Anaphylactic reaction (severe allergy).
  • Cardiac arrhythmias, including ventricular tachycardia.
  • Central nervous system toxicity such as seizures or loss of consciousness.
  • Methemoglobinemia.
  • Persistent numbness or motor weakness.
  • Respiratory depression.

Precautions & Warnings

When using lidocaine, careful assessment and monitoring are essential.

  • Patient assessment: evaluate cardiac history, liver function, and allergy status.
  • Dose calculation: base on patient weight, site of administration, and maximum recommended limits.
  • Monitoring: observe vital signs and neurologic status during epidural or intravenous use.
  • Contraindications: avoid in individuals with known lidocaine hypersensitivity.
  • Use with caution: patients with severe heart block, hepatic impairment, or electrolyte disturbances may be at higher risk.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Lidocaine may interact with other medications, altering its safety profile.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): increase risk of lidocaine toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): raise plasma lidocaine concentrations.
  • Beta‑blockers (e.g., propranolol): potentiate cardiac depressant effects.

Moderate Interactions (Monitor Closely)

  • Class II antiarrhythmics (e.g., metoprolol): may enhance bradycardia.
  • Diuretics (e.g., furosemide): alter plasma protein binding, affecting free lidocaine levels.
  • General anesthetics (e.g., propofol, volatile agents): additive central nervous system depression.

Frequently Asked Questions

Lidocaine Hydrochloride Laboratoire Aguettant is a sterile solution of the local anesthetic lidocaine. It is employed to produce rapid, reversible loss of sensation for minor surgical or dental procedures, to provide epidural analgesia during labor or surgery, to act as an intravenous antiarrhythmic agent, and to facilitate peripheral nerve blocks for regional anesthesia.

Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing sodium influx that is essential for depolarisation. By inhibiting the generation and propagation of nerve impulses, lidocaine stops the transmission of pain signals, resulting in a temporary loss of sensation in the area where it is administered.

The specific dose of lidocaine Hydrochloride Laboratoire Aguettant is determined by the prescribing clinician based on the intended use, patient weight, site of administration, and clinical guidelines. Only a qualified healthcare professional should set the dosage and administration schedule.

Safety data for lidocaine Hydrochloride during pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Use should only be considered when the potential benefit justifies any potential risk to the fetus or infant, and it must be prescribed by a qualified practitioner.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then replies with pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

Lidocaine is a medium‑duration amide‑type local anesthetic with a rapid onset, making it suitable for a wide range of procedures. Compared with shorter‑acting agents like procaine, lidocaine provides longer analgesia, while agents such as bupivacaine offer even longer duration but have a higher risk of cardiotoxicity. Choice depends on the clinical context and safety considerations.

Store lidocaine Hydrochloride Laboratoire Aguettant at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from light and moisture, and ensure the container is tightly sealed to maintain sterility.

Lidocaine Hydrochloride is supplied as a sterile solution for injection and can be administered via epidural, infiltration, intravenous, or subcutaneous routes. The specific technique—such as epidural catheter placement, local infiltration, or intravenous infusion—depends on the intended indication and is performed by a qualified healthcare professional.

The most serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias, central nervous system toxicity (seizures, loss of consciousness), methemoglobinemia, and respiratory depression. Prompt recognition and supportive management are essential if any of these events occur.

Lidocaine should be avoided in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, in those with severe heart block, significant hepatic impairment, or in patients taking medications that markedly increase lidocaine plasma levels without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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