Lidocaína Kabi (Lidocaine Hydrochloride Monohydrate)

Lidocaína Kabi is a local anesthetic used in the management of pain and surgical procedures involving peripheral and central nerves.

• Local anesthesia: produces reversible loss of sensation for minor surgeries and dental work.
• Regional anesthesia: enables epidural or spinal block for obstetric, orthopedic or abdominal procedures.
• Pain management: provides short‑term relief of acute severe pain, such as postoperative or trauma‑related pain.

• Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, stabilising the neuronal membrane and preventing the initiation and propagation of action potentials. By inhibiting sodium influx, it halts nerve impulse transmission, resulting in loss of sensation in the targeted area without affecting surrounding tissues.

Lidocaine may cause a range of adverse reactions, from mild to severe, depending on dose and route of administration.

Common Side Effects

• Tingling or numbness at the injection site
• Light‑headedness or dizziness
• Nausea or vomiting
• Metallic taste in the mouth
• Local irritation or erythema
• Transient visual disturbances

Serious or Rare Side Effects

• Cardiovascular collapse or severe hypotension
• Seizures or central nervous system toxicity
• Methemoglobinemia
• Anaphylactic or severe allergic reactions
• Cardiac arrhythmias, including ventricular tachycardia
• Respiratory depression or apnea

When using Lidocaína Kabi, clinicians should observe specific safety measures to minimise risk.

• Cardiac assessment: evaluate baseline heart rhythm and function before administration.
• CNS monitoring: watch for signs of toxicity such as tinnitus, circumoral numbness or seizures.
• Dose minimisation: use the lowest effective dose for the intended procedure.
• Hypersensitivity: avoid in patients with known lidocaine allergy.
• Hepatic impairment: consider dose reduction in severe liver disease.
• Store at controlled room temperature: keep in the original container, protect from light and moisture.

Lidocaine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

• Class I anti‑arrhythmics (e.g., quinidine, procainamide) – may increase cardiotoxicity.
• Strong CYP3A4 inhibitors (e.g., amiodarone, cimetidine) – can raise plasma lidocaine levels.

Moderate Interactions (Monitor Closely)

• Other local anesthetics – additive neuro‑ and cardiotoxic effects.
• Central nervous system depressants (e.g., benzodiazepines, opioids) – enhanced sedation.
• Beta‑blockers – may potentiate bradycardia when combined with lidocaine.