Product image of Lidocaine Hydrochloride Noridem (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lidocaine Hydrochloride Noridem

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lidocaine Hydrochloride Noridem (Lidocaine Hydrochloride Monohydrate)

Lidocaine Hydrochloride, the active ingredient in Lidocaine Hydrochloride Noridem, is a local anesthetic presented as a sterile solution for epidural, infiltration and intradermal use. It provides reversible nerve block for minor surgical, diagnostic and analgesic procedures in adult patients.
GNH India supplies Lidocaine Hydrochloride Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Lidocaine Hydrochloride is used in the local anesthetic class to temporarily block nerve transmission for various procedures.

  • Minor surgical or diagnostic procedures: provides rapid onset surface anesthesia for short‑duration interventions.
  • Epidural analgesia: delivers segmental pain relief during labor, obstetric or postoperative care.
  • Infiltration anesthesia: allows targeted numbness of tissues during suturing or minor excisions.
  • Intradermal anesthesia: facilitates painless skin testing or superficial dermatologic procedures.

How It Works

  • Lidocaine Hydrochloride reversibly binds to voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel. This blockade prevents the influx of sodium ions required for depolarization, thereby inhibiting initiation and propagation of nerve impulses and producing a temporary loss of sensation in the administered area.

Side Effects

Lidocaine Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Burning or stinging at the injection site.
  • Tingling or numbness extending beyond the target area.
  • Light‑headedness or dizziness.
  • Mild hypotension.

Serious or Rare Side Effects

  • Allergic reactions such as rash, urticaria or anaphylaxis.
  • Central nervous system toxicity manifesting as seizures or loss of consciousness.
  • Cardiac arrhythmias, including ventricular tachycardia.
  • Methemoglobinemia leading to cyanosis and reduced oxygen delivery.

Precautions & Warnings

When using Lidocaine Hydrochloride, clinicians should observe several safety measures.

  • Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics.
  • Dose minimization: employ the lowest effective concentration for the intended procedure.
  • Cardiovascular monitoring: watch for hypotension or arrhythmias, especially in high‑risk patients.
  • Hepatic function: use caution in patients with severe liver disease due to reduced metabolism.
  • Pregnancy considerations: avoid unless benefit outweighs potential risk, as data are limited.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lidocaine Hydrochloride can interact with other medicines that affect cardiac conduction or drug metabolism.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide) – may potentiate cardiotoxicity.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) – increase systemic lidocaine levels.
  • Beta‑blockers – can enhance bradycardia and hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics – cumulative toxicity risk.
  • Diuretics (e.g., furosemide) – may lower plasma protein binding, raising free lidocaine.
  • Anticonvulsants – may alter seizure threshold when lidocaine toxicity occurs.

Frequently Asked Questions

Lidocaine Hydrochloride Noridem is a sterile solution of the local anesthetic lidocaine. It is employed to provide temporary numbness for minor surgical or diagnostic procedures, epidural analgesia during labor or postoperative care, infiltration of tissues for suturing or excision, and intradermal anesthesia for skin testing or dermatologic interventions.

Lidocaine blocks voltage‑gated sodium channels on nerve membranes, stabilizing them in an inactive state. By preventing sodium influx, it stops the generation and propagation of action potentials, which interrupts the transmission of pain signals from the site of administration to the brain, resulting in localized loss of sensation.

The appropriate dose of Lidocaine Hydrochloride Noridem is determined by the prescribing clinician based on the specific procedure, patient age, weight, and health status. Dosage calculations consider the concentration of the solution, the route of administration, and any relevant safety limits to avoid toxicity.

Safety data for lidocaine use in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians are advised to discuss individual circumstances with the patient and consider alternative options when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lidocaine is an amide‑type local anesthetic with a rapid onset (1–3 minutes) and moderate duration (1–2 hours) for infiltration. Compared with bupivacaine, it has a shorter duration but a lower risk of cardiotoxicity. Compared with procaine (an ester), lidocaine offers faster onset and longer action, making it a common choice for many short‑procedural anesthetic needs.

Lidocaine Hydrochloride Noridem should be stored at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture, direct sunlight and extreme temperature fluctuations. Do not freeze the solution, and inspect for particulate matter before use.

The product is supplied as a sterile solution for injection. It can be administered epidurally, by infiltration into soft tissue, or intradermally, depending on the clinical indication. Administration is performed by a qualified healthcare professional using aseptic technique and appropriate dosing guidelines.

Serious adverse events include systemic toxicity leading to central nervous system symptoms such as seizures, cardiac arrhythmias or cardiac arrest, severe allergic reactions (anaphylaxis), and rare cases of methemoglobinemia. Prompt recognition and supportive management are essential if these events occur.

Patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe heart block, uncontrolled arrhythmias, or significant hepatic impairment should avoid this product. It is also contraindicated in patients with certain congenital cardiac conduction disorders unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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