Product image of Lidocaine Kade (Lidocaine) supplied by GNH India

Lidocaine Kade

Active Ingredient:
Lidocaine
Origin:
EU

Lidocaine Kade (Lidocaine)

Lidocaine, the active ingredient in Lidocaine Kade, is a local anesthetic presented as a rectal formulation for use in patients requiring rectal anesthesia. It provides local anesthesia for rectal procedures and helps relieve rectal pain.

GNH India supplies Lidocaine Kade as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Kade Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Lidocaine Kade is a local anesthetic used in the gastrointestinal tract to provide targeted pain control.

  • Rectal procedures: provides local anesthesia to facilitate minor surgical or diagnostic interventions.
  • Rectal pain: relieves discomfort associated with conditions such as hemorrhoids or proctitis.
  • Anal fissure: reduces pain during the healing phase.

How It Works

  • Lidocaine reversibly blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. By inhibiting sodium influx, it halts nerve impulse conduction in the targeted area, producing a rapid and localized loss of sensation without affecting systemic nerve function when used at appropriate concentrations.

Side Effects

Lidocaine Kade may cause adverse reactions at the site of administration or systemically.

Common Side Effects

  • Mild burning or stinging at the application site.
  • Localized itching or erythema.
  • Transient numbness extending slightly beyond the treated area.
  • Light‑headedness or dizziness.
  • Mild headache.
  • Nausea.

Serious or Rare Side Effects

  • Central nervous system toxicity (e.g., seizures, confusion).
  • Cardiovascular effects such as arrhythmias or hypotension.
  • Severe allergic reaction (anaphylaxis, angioedema).
  • Methemoglobinemia.
  • Respiratory depression.
  • Persistent numbness or motor weakness.

Precautions & Warnings

When using Lidocaine Kade, consider the following safety measures.

  • Assess patient history: verify no known allergy to amide‑type local anesthetics.
  • Use lowest effective dose: limit systemic absorption and reduce toxicity risk.
  • Avoid concurrent use with other sodium‑channel blockers: may potentiate cardiac effects.
  • Monitor for signs of toxicity: especially in patients with hepatic impairment or low body weight.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidocaine Kade can interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Class I antiarrhythmic drugs (e.g., quinidine, procainamide): increased risk of cardiac toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise systemic lidocaine concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: potential additive CNS depression.
  • General anesthetics (e.g., propofol, sevoflurane): enhanced depressant effects on the central nervous system.
  • Diuretics: may alter plasma protein binding, affecting lidocaine levels.

Frequently Asked Questions

Lidocaine Kade is used to provide local anesthesia during rectal procedures and to relieve rectal pain associated with conditions such as hemorrhoids, proctitis, or anal fissures. It works by numbing the targeted area, facilitating minor surgeries or diagnostic examinations without causing systemic anesthesia.

Lidocaine works by reversibly blocking voltage‑gated sodium channels on nerve fibers. This inhibition stops the influx of sodium ions needed for the generation and propagation of nerve impulses, resulting in a rapid loss of sensation in the area where the drug is applied.

The appropriate dose of Lidocaine Kade is determined by the prescribing healthcare professional based on the specific procedure, patient age, weight, and clinical condition. Only a qualified prescriber should set the dosage and administration schedule.

Safety data for Lidocaine Kade in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lidocaine is an amide‑type local anesthetic with a rapid onset and moderate duration, making it suitable for short‑term rectal procedures. Compared with agents like bupivacaine, lidocaine has a shorter half‑life and lower risk of prolonged motor block, but may require repeat dosing for longer procedures.

Lidocaine Kade should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and potency.

Lidocaine Kade is administered rectally, typically as a topical gel, ointment, or suppository applied directly to the mucosal surface of the rectum. The exact form and method are defined by the prescriber and the product’s labeling.

Serious risks include systemic toxicity leading to seizures, cardiac arrhythmias, severe allergic reactions (anaphylaxis), and methemoglobinemia. Prompt recognition of symptoms such as dizziness, tinnitus, metallic taste, or cardiovascular changes is essential, and medical attention should be sought immediately.

Patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe liver disease, or individuals taking medications that significantly raise lidocaine plasma levels (e.g., certain antiarrhythmics) should avoid using this product unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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