Product image of Lidocaine Orion (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lidocaine Orion

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lidocaine Orion (Lidocaine Hydrochloride Monohydrate)

Lidocaine Hydrochloride Monohydrate, the active ingredient in Lidocaine Orion, is a local anesthetic (amide type) presented as an intravenous solution for use in hospitals and clinical settings. It provides reversible loss of sensation for procedural anesthesia and can be administered intravenously to manage certain cardiac rhythm disturbances.

GNH India supplies Lidocaine Orion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Lidocaine Orion is employed in the management of nerve conduction and cardiac electrical activity disorders.

  • Local anesthesia: Provides reversible loss of sensation in targeted tissue for surgical or diagnostic procedures.
  • Ventricular arrhythmias: Used intravenously to suppress abnormal heart rhythms, particularly ventricular tachycardia, when other antiarrhythmics are ineffective.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in neuronal and cardiac cell membranes, stabilizing the inactive state of the channel. This inhibition prevents the rapid influx of sodium ions required for depolarization, thereby reducing the initiation and propagation of nerve impulses and abnormal cardiac action potentials.

Side Effects

Adverse reactions may occur with lidocaine administration and are categorized by frequency.

Common Side Effects

  • Dizziness or light‑headedness
  • Tingling or numbness at the injection site
  • Metallic taste in the mouth
  • Mild hypotension
  • Nausea or vomiting
  • Transient bradycardia

Serious or Rare Side Effects

  • Cardiac arrest or severe arrhythmias
  • Profound hypotension or cardiovascular collapse
  • Allergic reactions including rash, bronchospasm, or anaphylaxis
  • Central nervous system toxicity such as seizures
  • Methemoglobinemia
  • Respiratory depression

Precautions & Warnings

Lidocaine should be used with careful clinical monitoring and consideration of patient‑specific factors.

  • Cardiac monitoring: Observe ECG and blood pressure during intravenous administration.
  • Hepatic impairment: Adjust dose or monitor plasma levels in patients with liver dysfunction.
  • Allergy: Avoid use in individuals with known hypersensitivity to lidocaine or amide‑type anesthetics.
  • Conduction disorders: Use cautiously in patients with pre‑existing heart block or severe bradycardia.
  • Rapid bolus injection: Do not administer large IV bolus doses; inject slowly to reduce toxicity risk.
  • Store at controlled room temperature: Keep below 25 °C, in original container, protected from moisture and light.

Avoid Interactions

Lidocaine may interact with other medications that affect cardiac conduction or drug metabolism.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): additive effects on cardiac conduction.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase lidocaine plasma concentrations.
  • CYP1A2 inducers (e.g., carbamazepine, phenobarbital): reduce lidocaine effectiveness.

Moderate Interactions (Monitor Closely)

  • Beta‑adrenergic blockers: may enhance bradycardic response.
  • Diuretics (e.g., furosemide): can alter plasma protein binding and free drug levels.
  • General anesthetics (e.g., propofol, volatile agents): may potentiate central nervous system depression.

Frequently Asked Questions

Lidocaine Orion is a sterile intravenous formulation of lidocaine hydrochloride used to provide local anesthesia for surgical or diagnostic procedures and to treat certain ventricular cardiac arrhythmias when rapid rhythm control is required.

Lidocaine blocks voltage‑gated sodium channels on neuronal and cardiac membranes, preventing the rapid influx of sodium ions that initiates and propagates action potentials. This stabilizes cell membranes, reducing nerve signal transmission and suppressing abnormal cardiac electrical activity.

The dosage of Lidocaine Orion is determined by the prescribing clinician based on the specific indication, patient weight, age, and clinical condition. Healthcare professionals calculate the appropriate dose and infusion rate according to established guidelines.

Safety data for lidocaine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Lidocaine is a class Ib antiarrhythmic that preferentially affects ischemic or depolarized cardiac tissue, offering rapid onset when given intravenously. Unlike class Ia or III agents, it has minimal effect on normal conduction and a shorter half‑life, making it useful for acute ventricular tachycardia but less suitable for long‑term rhythm control.

Lidocaine Orion should be stored at controlled room temperature, below 25 °C, in its original sealed container. Protect the solution from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze; discard any product that appears discolored or contains particles.

Lidocaine Orion is administered intravenously by a qualified healthcare professional. For local anesthesia, it is injected near the target nerve or tissue. For arrhythmia control, it is given as a slow IV bolus followed by an infusion, with continuous cardiac monitoring.

Serious risks include severe cardiovascular toxicity such as cardiac arrest, profound hypotension, and life‑threatening arrhythmias, as well as central nervous system toxicity manifesting as seizures or respiratory depression. Prompt recognition and supportive measures are essential if these events occur.

Patients with known hypersensitivity to lidocaine or other amide‑type local anesthetics, those with severe heart block, significant bradycardia, or uncontrolled heart failure should avoid Lidocaine Orion unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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