Product image of Lidocaïne/Prilocaïne Biogaran (Lidocaine, Prilocaine) supplied by GNH India

Lidocaïne/Prilocaïne Biogaran

Active Ingredient:
Lidocaine, Prilocaine
Origin:
EU

Lidocaïne/Prilocaïne Biogaran (Lidocaine, Prilocaine)

Lidocaine, the active ingredient in Lidocaïne/Prilocaïne Biogaran, is a local anesthetic presented as a topical formulation for surface anesthesia. It provides reversible nerve block for minor skin procedures, venipuncture and other superficial interventions.
GNH India supplies Lidocaïne/Prilocaïne Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bouchara Recordati

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Indications & Clinical Uses

  • Lidocaine/Prilocaine is a topical local anesthetic used to achieve surface numbness for minor procedures.
  • Minor skin procedures: provides temporary loss of sensation for biopsies, laser therapy or minor excisions.
  • Venipuncture and cannulation: reduces pain during blood draws and intravenous line placement.
  • Dermatologic procedures: facilitates cosmetic or therapeutic skin treatments such as dermabrasion or chemical peels.

How It Works

  • Lidocaine and prilocaine act by reversibly blocking voltage‑gated sodium channels in neuronal membranes, which inhibits the initiation and propagation of nerve impulses. This blockade prevents the transmission of pain signals, resulting in localized loss of sensation at the site of application.

Side Effects

Lidocaine/Prilocaine may cause local and systemic adverse reactions.

Common Side Effects

  • Mild skin irritation at the application site.
  • Transient erythema or redness.
  • Pruritus or itching where applied.
  • Slight burning sensation during initial application.
  • Dryness or peeling of the skin.

Serious or Rare Side Effects

  • Allergic contact dermatitis with swelling or vesicles.
  • Systemic toxicity presenting as dizziness, tinnitus, or seizures.
  • Methemoglobinemia, a rare blood disorder causing cyanosis.
  • Cardiac arrhythmias in cases of excessive absorption.
  • Severe hypotension or respiratory depression.

Precautions & Warnings

Before using Lidocaine/Prilocaine, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to amide‑type local anesthetics.
  • Application area: avoid use on large surface areas, broken skin, or mucous membranes.
  • Age considerations: use with caution in neonates, infants, and the elderly.
  • Concurrent medications: be aware of agents that may increase systemic absorption or toxicity.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lidocaine/Prilocaine can interact with other medicines, affecting safety and efficacy.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase systemic toxicity.
  • Beta‑blockers (e.g., propranolol): can potentiate cardiac effects.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative dose may raise toxicity risk.
  • Monoamine oxidase inhibitors: may alter metabolism of lidocaine.
  • CYP2D6 inhibitors: could reduce clearance of lidocaine, increasing plasma levels.

Frequently Asked Questions

Lidocaïne/Prilocaïne Biogaran is a prescription‑only topical formulation that provides local anesthesia for minor skin procedures, venipuncture, cannulation, and various dermatologic interventions. It works by numbing the surface of the skin, reducing pain and discomfort during short‑duration procedures.

Lidocaine, together with prilocaine, blocks voltage‑gated sodium channels in peripheral nerves. This inhibition prevents the generation and propagation of action potentials, thereby stopping pain signals from reaching the brain and producing a temporary loss of sensation at the site of application.

The appropriate amount and frequency of application are determined by the prescribing healthcare professional based on the procedure, patient age, and treatment area. The product is applied as a thin layer to intact skin and covered according to the clinician’s instructions.

Safety data for use in pregnancy and lactation are limited. The prescriber should evaluate the potential benefits against possible risks before recommending the product to pregnant or nursing individuals.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lidocaine/prilocaine combines two amide‑type anesthetics, offering broader coverage and a slightly longer duration of action compared with single‑agent products such as lidocaine alone. This combination can provide more effective surface anesthesia for procedures that require deeper or more sustained numbness.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use to maintain product integrity.

The medication is applied topically to clean, intact skin. A thin layer is spread over the intended area, and the site may be covered with an occlusive dressing if recommended by the clinician. The product should not be injected or used on mucous membranes unless specifically directed.

Serious adverse events, though rare, include systemic toxicity such as central nervous system symptoms (e.g., seizures), cardiovascular effects (arrhythmias, hypotension), allergic contact dermatitis, and methemoglobinemia. Immediate medical attention is required if any of these symptoms develop.

Patients with known hypersensitivity to lidocaine, prilocaine, or other amide‑type local anesthetics should avoid this product. It is also contraindicated on large, broken, or infected skin areas, and caution is advised in neonates, infants, and individuals with severe cardiac or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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