Product image of Lidocaine Prilocaine Zentiva (Lidocaine, Prilocaine) supplied by GNH India

Lidocaine Prilocaine Zentiva

Active Ingredient:
Lidocaine, Prilocaine
Origin:
EU

Lidocaine Prilocaine Zentiva (Lidocaine, Prilocaine)

Lidocaine and Prilocaine, the active ingredients in Lidocaine Prilocaine Zentiva, are local anesthetics presented as a topical formulation for cutaneous use. They provide rapid, reversible surface anesthesia for minor skin and mucous membrane procedures, helping to reduce pain and discomfort during dermatological interventions.

GNH India supplies Lidocaine Prilocaine Zentiva as a licensed, GDP‑compliant international pharmaceutical product, serving hospitals, pharmacies and clinics worldwide with reliable sourcing and regulatory support. The product complies with EU quality standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

Lidocaine Prilocaine Zentiva is a topical anesthetic used to numb skin and mucous membranes for minor procedures.

  • Local anesthesia of skin and mucous membranes: provides temporary loss of sensation for minor surgical or diagnostic interventions.
  • Pain relief for minor dermatological procedures: reduces discomfort during biopsies, laser therapy, or excisions.
  • Pre‑procedural analgesia for superficial needle insertions: numbs the area before injections or blood draws.

How It Works

  • Lidocaine and prilocaine act by reversibly inhibiting voltage‑gated sodium channels in neuronal membranes, which blocks the initiation and propagation of action potentials. This prevents depolarization of sensory nerve fibers, resulting in a loss of pain perception in the applied area while preserving other physiological functions.

Side Effects

Adverse reactions may occur following topical application of lidocaine/prilocaine combinations.

Common Side Effects

  • Mild burning or stinging sensation at the application site
  • Transient erythema or redness
  • Localized itching or pruritus
  • Tingling or paresthesia
  • Mild swelling of the applied area

Serious or Rare Side Effects

  • Allergic contact dermatitis with rash or edema
  • Systemic toxicity (e.g., CNS symptoms such as dizziness, seizures) if excessive area is treated
  • Methemoglobinemia, a rare blood disorder associated with prilocaine
  • Severe cardiac arrhythmias in cases of systemic absorption
  • Anaphylactic reaction requiring emergency care

Precautions & Warnings

Before using Lidocaine Prilocaine Zentiva, consider the following safety measures.

  • Assess for allergy: avoid use in patients with known hypersensitivity to amide‑type local anesthetics.
  • Limit application area: do not exceed the recommended surface area to prevent systemic absorption.
  • Avoid use on broken skin: apply only to intact epidermis or mucosa.
  • Use with caution in patients with cardiovascular or hepatic impairment.
  • Pregnancy and lactation: consult the prescriber as safety data are limited.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidocaine Prilocaine Zentiva may interact with other medicines; awareness of potential interactions helps maintain safety.

Major Interactions (Avoid)

  • Concurrent use with other potent local anesthetics: may increase risk of systemic toxicity.
  • Co‑administration with monoamine oxidase inhibitors (MAOIs): may potentiate central nervous system effects.

Moderate Interactions (Monitor Closely)

  • Use with CYP450 inhibitors (e.g., cimetidine) may slow lidocaine metabolism.
  • Concomitant use of drugs affecting cardiac conduction (e.g., class I antiarrhythmics) may enhance cardiac effects.
  • Combination with methemoglobin‑inducing agents (e.g., dapsone) may raise the risk of methemoglobinemia.

Frequently Asked Questions

Lidocaine Prilocaine Zentiva is a topical anesthetic applied to the skin or mucous membranes to provide temporary numbness. It is commonly used for minor dermatological procedures, superficial needle insertions, and any situation where short‑term surface analgesia is required.

Both lidocaine and prilocaine block voltage‑gated sodium channels on neuronal membranes, preventing the initiation and spread of nerve impulses. This reversible inhibition stops the transmission of pain signals from the treated area, resulting in localized anesthesia without affecting deeper tissues.

The exact amount to apply is determined by the prescribing clinician based on the size of the treatment area and the procedure. Typically, a thin layer is spread over the target site and covered with a suitable dressing for the time recommended by the healthcare professional.

Safety data for topical lidocaine/prilocaine use in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks and decide whether the product is appropriate for each individual patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with single‑agent products such as benzocaine or lidocaine alone, the lidocaine‑prilocaine combination often provides a broader onset and slightly longer duration of anesthesia. The dual‑action can improve patient comfort for procedures that require both rapid onset and sustained numbness, while maintaining a similar safety profile when used as directed.

Store Lidocaine Prilocaine Zentiva at room temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in its original packaging until use to maintain product stability.

The product is applied topically to intact skin or mucous membranes. After cleaning the area, a thin, even layer is spread over the target site and may be covered with an occlusive dressing if recommended. The duration of application is guided by the prescriber, typically ranging from a few minutes to up to an hour.

Serious adverse events, although rare, include systemic toxicity such as central nervous system symptoms (dizziness, seizures) and cardiac arrhythmias if large surface areas are treated. Methemoglobinemia, a blood disorder linked to prilocaine, can also occur, especially in susceptible individuals or when excessive amounts are absorbed.

Individuals with a known hypersensitivity to lidocaine, prilocaine, or any amide‑type local anesthetic should avoid this product. It is also contraindicated on broken or inflamed skin, and caution is advised for patients with severe cardiac, hepatic, or renal impairment until a clinician evaluates the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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