Product image of Lidocaine Sans Conservateur Aguettant (Lidocaine Hydrochloride Monohydrate) supplied by GNH India

Lidocaine Sans Conservateur Aguettant

Active Ingredient:
Lidocaine Hydrochloride Monohydrate
Origin:
EU

Lidocaine Sans Conservateur Aguettant (Lidocaine Hydrochloride Monohydrate)

Lidocaine, the active ingredient in Lidocaine Sans Conservateur Aguettant, is a local anesthetic presented as a sterile solution for epidural, infiltration and intramuscular use. It provides rapid, reversible loss of sensation for surgical and diagnostic procedures in adult patients.
GNH India supplies Lidocaine Sans Conservateur Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Lidocaine is a local anesthetic used to block nerve conduction in various clinical settings.

  • Local anesthesia: produces rapid numbness for minor surgical or diagnostic procedures.
  • Epidural analgesia: provides pain relief during labor, childbirth or postoperative recovery.
  • Infiltration anesthesia: enables targeted numbing of skin, mucous membranes or superficial tissues.
  • Intramuscular nerve block: facilitates regional anesthesia for orthopedic or musculoskeletal interventions.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel and preventing the influx of sodium ions. This inhibition halts the initiation and propagation of action potentials, thereby interrupting nerve impulse transmission and producing a reversible loss of sensation in the treated area.

Side Effects

Adverse reactions may occur following administration of lidocaine.

Common Side Effects

  • Tingling or numbness at the injection site
  • Mild dizziness or light‑headedness
  • Transient hypotension
  • Nausea or mild gastrointestinal upset
  • Localized swelling or erythema

Serious or Rare Side Effects

  • Cardiac arrhythmias, including ventricular tachycardia
  • Seizures or central nervous system excitation
  • Methemoglobinemia leading to cyanosis
  • Severe allergic reactions such as anaphylaxis
  • Persistent motor block or prolonged numbness
  • Respiratory depression in high systemic exposure

Precautions & Warnings

Proper assessment and monitoring are essential when using lidocaine.

  • Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics.
  • Cardiovascular status: monitor patients with conduction disorders or heart disease.
  • Dosage limits: avoid exceeding the recommended total dose for the specific route.
  • Concurrent CNS depressants: use caution with other agents that lower seizure threshold.
  • Pregnancy and lactation: evaluate risk‑benefit before administration.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidocaine may interact with other medicines, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): increase risk of cardiotoxicity.
  • Beta‑blockers (e.g., propranolol): may potentiate bradycardia and hypotension.
  • Inhalational anesthetics (e.g., halothane): enhance central nervous system depression.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase bleeding tendency when combined with regional blocks.
  • Opioids: additive sedative and respiratory depressant effects.
  • CYP3A4 inhibitors (e.g., erythromycin): can alter lidocaine metabolism and plasma levels.

Frequently Asked Questions

Lidocaine Sans Conservateur Aguettant is a preservative‑free lidocaine formulation used to provide local, epidural, infiltration and intramuscular anesthesia. It is employed in surgical, obstetric, dental and diagnostic procedures to achieve rapid, reversible loss of sensation in the targeted area.

Lidocaine blocks voltage‑gated sodium channels on nerve membranes, stabilising them in an inactive state. By preventing sodium influx, it stops the generation and propagation of action potentials, thereby interrupting nerve signal transmission and producing a temporary loss of pain and sensation.

The specific dose of Lidocaine Sans Conservateur Aguettant is determined by the prescribing clinician based on the intended route, patient weight, age, and the procedure being performed. Healthcare professionals calculate the appropriate volume and concentration to stay within safe maximum limits.

Safety data for lidocaine in pregnancy and lactation are limited, and the drug is generally used only when the potential benefit justifies any potential risk to the fetus or infant. Clinicians should assess each case individually and follow local guidelines regarding use in pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Lidocaine is an amide‑type local anesthetic with a rapid onset (1–3 minutes) and moderate duration (1–2 hours). Compared with agents such as bupivacaine, it has a shorter duration but a lower risk of cardiotoxicity at equivalent doses, making it a common choice for short‑procedural anesthesia.

Lidocaine Sans Conservateur Aguettant should be stored at room temperature, below 25 °C, in its original packaging. The container should be kept away from direct sunlight, moisture and extreme temperature fluctuations to maintain sterility and potency.

The product is supplied as a sterile solution for injection and is administered by a qualified healthcare professional via epidural, infiltration or intramuscular routes. The injection technique follows standard aseptic procedures, and the volume injected is calculated according to the clinical indication and patient factors.

Serious risks include cardiac arrhythmias, seizures, methemoglobinemia and severe allergic reactions such as anaphylaxis. These events are more likely with excessive dosing, rapid intravascular injection, or in patients with pre‑existing cardiac or metabolic disorders, and require immediate medical intervention.

Lidocaine is contraindicated in patients with known hypersensitivity to amide‑type local anesthetics, those with severe heart block or uncontrolled arrhythmias, and individuals with certain metabolic disorders that predispose to methemoglobinemia. Clinicians should also exercise caution in patients with liver disease or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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