Lidocaine Sans Conservateur Aguettant (Lidocaine Hydrochloride Monohydrate)

Lidocaine works by blocking voltage‑gated sodium channels on nerve membranes. This inhibition prevents the rapid influx of sodium ions needed for depolarisation, thereby stopping the generation and propagation of action potentials. The result is a reversible interruption of nerve signal transmission, producing loss of sensation in the targeted area.

The appropriate dose of lidocaine is determined by the prescribing clinician based on the specific procedure, route of administration, patient weight, age, and overall health status. Dosage calculations also consider the concentration of the solution and any concurrent medications. The prescriber sets the exact amount to be administered.

The safety of lidocaine during pregnancy and lactation has not been definitively established, and it is classified as a Category C/unknown drug. Clinicians weigh potential benefits against possible risks, and it is generally used only when essential. Breastfeeding mothers should consult their healthcare provider before exposure.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lidocaine has a rapid onset of action (1–3 minutes) and a moderate duration (30–120 minutes), whereas bupivacaine has a slower onset (5–10 minutes) but a longer duration (up to several hours). Lidocaine is often chosen for shorter procedures, while bupivacaine is preferred when prolonged analgesia is needed. Both share similar mechanisms but differ in potency and toxicity profiles.

Lidocaine Sans Conservateur Aguettant should be stored at room temperature, below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct sunlight, and avoid freezing. Ensure the container is tightly sealed to maintain sterility until use.

For epidural administration, lidocaine is injected into the epidural space using a specialized needle under aseptic technique, often with imaging guidance. Infiltration involves injecting the solution directly into the tissue surrounding a surgical site. Intramuscular administration delivers the drug into a muscle belly to achieve deep tissue anesthesia. All routes require careful dose calculation and monitoring.

Serious risks include cardiovascular toxicity such as arrhythmias and severe hypotension, central nervous system toxicity leading to seizures, methemoglobinemia, and life‑threatening allergic reactions (anaphylaxis). Continuous monitoring of cardiac rhythm, blood pressure, and neurological status is essential, especially when high doses or rapid injections are used.

Lidocaine should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, severe hepatic impairment, or pre‑existing cardiac conduction abnormalities that could be exacerbated by sodium‑channel blockade. Caution is also advised in patients taking medications that significantly inhibit its metabolism or in those with severe anemia or low plasma protein levels.