Lidocaine Vaseline Kruidvat (Lidocaine)

• Lidocaine Vaseline Kruidvat is a topical local anesthetic applied to the rectal mucosa to alleviate pain in several anorectal disorders.
• Hemorrhoidal pain: temporary relief of discomfort caused by internal or external hemorrhoids.
• Anal fissure pain: reduction of spasm and pain during bowel movements.
• Proctitis irritation: soothing of mild inflammatory irritation of the rectal lining.

• Lidocaine blocks voltage‑gated sodium channels on peripheral nerve membranes, stabilising the neuronal membrane and preventing the initiation and propagation of action potentials. This inhibition reduces the transmission of pain signals from the rectal mucosa, producing a localized numbing effect without systemic anesthetic activity.

Lidocaine Vaseline Kruidvat may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Burning or stinging at the application site.
• Mild itching or erythema.
• Transient numbness extending beyond the intended area.
• Dryness of the surrounding skin.
• Minor swelling or edema.

Serious or Rare Side Effects

• Allergic reaction: hives, swelling of face or throat, difficulty breathing.
• Systemic toxicity: dizziness, tinnitus, blurred vision, seizures.
• Severe skin irritation or ulceration at the site.
• Cardiac arrhythmias in cases of excessive absorption.
• Methemoglobinemia, a rare blood disorder.

• Before using Lidocaine Vaseline Kruidvat, consider the following safety measures.
• Allergy assessment: avoid use if you have known hypersensitivity to lidocaine or other amide‑type anesthetics.
• Application limit: use only the amount prescribed; excessive application can increase systemic absorption.
• Mucosal integrity: do not apply to broken skin, open wounds, or inflamed mucosa beyond the intended indication.
• Concurrent anesthetics: avoid using other topical anesthetics in the same area to prevent additive toxicity.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Lidocaine can interact with other medicines that affect cardiac conduction or metabolism.

Major Interactions (Avoid)

• Class I antiarrhythmics (e.g., quinidine, procainamide): may potentiate cardiac toxicity.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): can increase lidocaine plasma levels.
• Other local anesthetics: additive risk of systemic toxicity.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: may enhance bradycardic effects.
• Diuretics: can alter plasma protein binding, affecting lidocaine concentration.
• Anticoagulants: monitor for increased bleeding if mucosal injury occurs.