Product image of Lidofast (Lidocaine Hydrochloride) supplied by GNH India

Lidofast

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Lidofast (Lidocaine Hydrochloride)

Lidocaine, the active ingredient in Lidofast, is a local anesthetic presented as a sterile solution for urethral use. It provides temporary loss of sensation to the urethral mucosa, facilitating diagnostic and therapeutic procedures and relieving urethral discomfort. It is indicated for short‑term anesthesia during procedures such as cystoscopy, urethral dilation, and catheter insertion, providing rapid onset and reversible effect.

GNH India supplies Lidofast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality assurance and regulatory compliance.

Manufacturer / TM Owner

Angelini Pharma S.P.A.

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Indications & Clinical Uses

Lidofast (lidocaine) is used as a local anesthetic applied to the urethral mucosa to achieve temporary sensory blockade.

  • Cystoscopic procedures: provides analgesia and reduces discomfort during bladder and urethral examination.
  • Urethral catheterization: eases insertion and removal by numbing the urethral lining.
  • Urethral dilation: facilitates smooth passage of dilators by minimizing pain and spasm.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the rapid influx of sodium ions required for depolarization. This inhibition stops the generation and propagation of nerve impulses, resulting in reversible loss of sensation in the area where the drug is applied.

Side Effects

Lidofast may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Burning or stinging sensation at the application site
  • Mild local irritation or erythema
  • Transient dizziness or light‑headedness
  • Nausea
  • Headache
  • Mild metallic taste

Serious or Rare Side Effects

  • Seizures or convulsions
  • Cardiac arrhythmias or conduction disturbances
  • Methemoglobinemia
  • Severe allergic reaction (anaphylaxis)
  • Respiratory depression
  • Persistent numbness beyond expected duration

Precautions & Warnings

When using Lidofast, several precautions should be observed to minimize risk and ensure safe administration.

  • Allergy assessment: confirm no known hypersensitivity to lidocaine or amide‑type anesthetics
  • Dosage accuracy: use the prescribed volume and concentration only
  • Cardiac conditions: avoid in patients with severe heart block or conduction abnormalities
  • Liver impairment: adjust use in patients with significant hepatic dysfunction
  • Concurrent CNS depressants: monitor for enhanced central nervous system effects
  • Store at ambient temperature: keep in original container, protect from moisture and light

Avoid Interactions

Lidofast can interact with other medicines, altering its safety profile or effectiveness.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may cause severe cardiotoxicity
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase lidocaine plasma levels
  • Epinephrine in high concentrations: can potentiate systemic toxicity

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: additive neuro‑ or cardiotoxic effects
  • Beta‑blockers: may enhance bradycardia
  • Diuretics (e.g., furosemide): may increase plasma lidocaine concentration

Frequently Asked Questions

Lidofast contains lidocaine, a local anesthetic that is applied to the urethral mucosa to provide temporary numbness. It is used to reduce pain and discomfort during procedures such as cystoscopy, urethral catheterization, and urethral dilation.

Lidocaine blocks voltage‑gated sodium channels on nerve cells, preventing the rapid influx of sodium ions needed for depolarisation. This stops nerve impulse transmission, resulting in reversible loss of sensation in the treated area.

The dose of Lidofast is determined by the prescribing healthcare professional based on the specific procedure, patient characteristics, and clinical setting. Only the prescriber’s instructions should be followed.

Safety data for lidocaine administered urethrally during pregnancy or lactation are limited. The product should only be used if the potential benefit justifies any possible risk, and the decision must be made by the treating physician.

Enquiries are submitted through the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lidofast’s active ingredient, lidocaine, is an amide‑type local anesthetic with a rapid onset and moderate duration. Compared with ester‑type agents, lidocaine generally offers a lower risk of allergic reactions and is widely used for short‑term mucosal anesthesia.

Lidofast should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain its sterility and potency.

Lidofast is administered as a sterile urethral solution. The prescriber instills the recommended volume directly into the urethra using a compatible applicator or catheter, following aseptic technique.

Serious risks include seizures, severe cardiac arrhythmias, methemoglobinemia, anaphylactic reactions and respiratory depression. Immediate medical attention is required if any of these symptoms occur.

Lidofast should be avoided in patients with known hypersensitivity to lidocaine or other amide‑type anesthetics, in those with severe cardiac conduction disorders, and in individuals with significant hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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